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Cornelia Wolf, H. Haubelt, H. Pauer, B. Hinney, C. Krome-Cesar, T. Legler, P. Hellstern, G. Emons, B. Zoll, M. Köhler (2003)
Recurrent Pregnancy Loss and Its Relation to FV Leiden, FII G20210A and Polymorphisms of Plasminogen Activator and Plasminogen Activator InhibitorPathophysiology of Haemostasis and Thrombosis, 33
C. Coulam, D. Clark, A. Beer, W. Kutteh, R. Silver, J. Kwak, M. Stephenson (1997)
Current Clinical Options for Diagnosis and Treatment of Recurrent Spontaneous AbortionAmerican Journal of Reproductive Immunology, 38
E. Zorio, J. Gilabert-Estellés, F. España, L. Ramón, R. Cosín, A. Estellés (2008)
Fibrinolysis: the key to new pathogenetic mechanisms.Current medicinal chemistry, 15 9
Xuejiao Li, Yu-kun Liu, Rui Zhang, Jian-ping Tan, Libin Chen, Yinglin Liu (2015)
Meta-Analysis of the Association between Plasminogen Activator Inhibitor-1 4G/5G Polymorphism and Recurrent Pregnancy LossMedical Science Monitor : International Medical Journal of Experimental and Clinical Research, 21
V. Djordjevic, M. Gvozdenov, I. Pruner, B. Tomić, M. Kovač, N. Antonijević, D. Radojkovic (2013)
The prevalence of PAI-1 4G/5G gene variant in Serbian populationMedicinski Glasnik Specijalne Bolnice za Bolesti Štitaste Žlezde i Bolesti Metabolizma "Zlatibor", 18
Tin-Chiu Li, M. Makris, M. Tomsu, E. Tuckerman, S. Laird (2002)
Recurrent miscarriage: aetiology, management and prognosis.Human reproduction update, 8 5
(2010)
Research 4 G / 5 G polymorphism of PAI-1 gene is associated with multiple organ dysfunction and septic shock in pneumonia induced severe sepsis : prospective , observational , genetic study
J. Bonde, K. Jørgensen, M. Bonzini, K. Palmer (2013)
Miscarriage and occupational activity: a systematic review and meta-analysis regarding shift work, working hours, lifting, standing, and physical workload.Scandinavian journal of work, environment & health, 39 4
H. McNulty, M. McKinley, Barbara Wilson, J. Mcpartlin, J. Strain, D. Weir, J. Scott (2002)
Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements.The American journal of clinical nutrition, 76 2
L. Sun, H. Lv, W. Wei, D. Zhang, Y. Guan (2010)
Angiotensin-Converting enzyme D/I and plasminogen activator inhibitor-1 4G/5G gene polymorphisms are associated with increased risk of spontaneous abortions in polycystic ovarian syndromeJournal of Endocrinological Investigation, 33
C. Glueck, H. Phillips, Daniel Cameron, Ping Wang, R. Fontaine, Sarah Moore, L. Sieve-Smith, T. Tracy (2000)
The 4G/4G polymorphism of the hypofibrinolytic plasminogen activator inhibitor type 1 gene: an independent risk factor for serious pregnancy complications.Metabolism: clinical and experimental, 49 7
B. Toth, Franziska Vocke, N. Rogenhofer, K. Friese, Christian Thaler, P. Lohse (2008)
Paternal thrombophilic gene mutations are not associated with recurrent miscarriage.American journal of reproductive immunology, 60 4
M. Stephenson (1996)
Frequency of factors associated with habitual abortion in 197 couples.Fertility and sterility, 66 1
P. Eriksson, B. Kallin, F. Hooft, P. Båvenholm, A. Hamsten (1995)
Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction.Proceedings of the National Academy of Sciences of the United States of America, 92 6
S. Pandey, A. Pandey, U. Chauhan, A. Tripathi, J. Tripathi, Sanjeev Dubey, Rishabh Saket (2015)
RECURRENT PREGNANCY LOSS AND ASSOCIATION OF MTHFR, PAI-1 AND ACE GENE POLYMORPHISMS IN WOMENClinical & Biomedical Research, 1
P. Frosst, H. Blom, R. Milos, P. Goyette, C. Sheppard, R. Matthews, G. Boers, M. Heijer, L. Kluijtmans, L. Heuve, R. Rozen (1995)
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductaseNature Genetics, 10
Hui Chen, S. Nie, Ming Lu (2015)
Association between Plasminogen Activator Inhibitor‐1 Gene Polymorphisms and Recurrent Pregnancy Loss: A Systematic Review and Meta‐AnalysisAmerican Journal of Reproductive Immunology, 73
A. Biswas, P. Choudhry, A. Mittal, A. Meena, R. Ranjan, V. Choudhry, R. Saxena (2008)
Recurrent Abortions in Asian Indians: No Role of Factor V Leiden Hong Kong/Cambridge Mutation and MTHFR PolymorphismClinical and Applied Thrombosis/Hemostasis, 14
N. Yamada, T. Arinami, K. Yamakawa‐Kobayashi, Hideki Watanabe, S. Sohda, H. Hamada, T. Kubo, H. Hamaguchi (2000)
The 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with severe preeclampsiaJournal of Human Genetics, 45
Astrid Engbersen, D. Franken, G. Boers, E. Stevens, F. Trijbels, H. Blom (1995)
Thermolabile 5,10-methylenetetrahydrofolate reductase as a cause of mild hyperhomocysteinemia.American journal of human genetics, 56 1
N. Kim, Yoon Choi, M. Kang, D. Choi, S. Cha, Myung An, Suman Lee, Mingull Jeung, J. Ko, D. Oh (2006)
Influence of combined methylenetetrahydrofolate reductase (MTHFR) and thymidylate synthase enhancer region (TSER) polymorphisms to plasma homocysteine levels in Korean patients with recurrent spontaneous abortion.Thrombosis research, 117 6
C. Hoţoleanu, Eva Chouky (2012)
Hyperhomocysteinemia and methylenetetrahydrofolate reductase polymorphism in a patient with coronary artery disease and repetitive miscarriages.Romanian journal of internal medicine = Revue roumaine de medecine interne, 50 4
Aim: The objective of this study was to investigate a possible correlation between the plasminogen activator inhibitor-1 (PAI-1) and methylene tetrahydrofolate reductase (MTHFR) polymorphisms and unexplained spontaneous miscarriages (SM). Materials and Methods: PAI-1 polymorphisms were evaluated in 150 women with pregnancy in their history. One hundred women with a history of SM formed the study group and 50 women with normal pregnancies served as the control group. Also, the combination of PAI-1 and MTHFR polymorphisms were evaluated in 138 women out of a total of 150, which included 92 women with SM in their history compared to 46 women in the control group. For statistical analysis, χ<sup>2</sup> test, Phi, and Cramer V tests were used; p < 0.05 was taken as a statistically significant result. Results: Our findings show: (a) the correlation between SM and PAI-1 mutations reaches statistical significance (p = 0.026); (b) there was a statistically significant difference between heterozygous PAI-1 in women with only 1 SM compared to the control group (p = 0.047); (c) the comparison of combinations of both mutations, PAI-1 and MTHFR, with the control group demonstrates statistical significance in favor of women with SM and both mutations (p = 0.022). Conclusion: PAI-1 and MTHFR polymorphisms may play an important role in pregnancy complications because heterozygous PAI-1 mutations and a combination of both PAI-1 and MTHFR mutations might contribute to SM.
Acta Haematologica – Karger
Published: Jan 1, 2017
Keywords: Gene polymorphisms; Methylene tetrahydrofolate reductase; Plasminogen activator inhibitor-1; Spontaneous miscarriages
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