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Metastatic Gliosarcoma: Cytopathologic Characteristics with Histopathologic Correlations

Metastatic Gliosarcoma: Cytopathologic Characteristics with Histopathologic Correlations Gliosarcoma is a rare variant of glioblastoma multiforme characterized by a biphasic pattern of glial and mesenchymal differentiation. Fine-needle aspiration (FNA) is routinely employed to diagnose a number of primary and secondary malignancies in a variety of clinical settings. Herein, we describe the cytomorphologic features of a gliosarcoma metastatic to an extracranial location accompanied by corresponding clinico-radiologic and histopathologic findings in a 51-year-old man with a posterior mediastinal mass. The cytologic smears displayed a pleomorphic tumor comprised of spindled and epithelioid malignant cells. This case illustrates the ability of FNA to adequately diagnose a rare malignancy in the appropriate clinico-radiologic setting. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Cytologica Karger

Metastatic Gliosarcoma: Cytopathologic Characteristics with Histopathologic Correlations

Acta Cytologica , Volume 60 (5): 5 – Jan 1, 2016

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References (24)

Publisher
Karger
Copyright
© 2016 S. Karger AG, Basel
ISSN
0001-5547
eISSN
1938-2650
DOI
10.1159/000448509
Publisher site
See Article on Publisher Site

Abstract

Gliosarcoma is a rare variant of glioblastoma multiforme characterized by a biphasic pattern of glial and mesenchymal differentiation. Fine-needle aspiration (FNA) is routinely employed to diagnose a number of primary and secondary malignancies in a variety of clinical settings. Herein, we describe the cytomorphologic features of a gliosarcoma metastatic to an extracranial location accompanied by corresponding clinico-radiologic and histopathologic findings in a 51-year-old man with a posterior mediastinal mass. The cytologic smears displayed a pleomorphic tumor comprised of spindled and epithelioid malignant cells. This case illustrates the ability of FNA to adequately diagnose a rare malignancy in the appropriate clinico-radiologic setting.

Journal

Acta CytologicaKarger

Published: Jan 1, 2016

Keywords: Gliosarcoma; Fine-needle aspiration; Cytopathology; Extracranial metastasis; Glioblastoma multiforme

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