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Unbalanced Translocation der(7)t(7q;11q): A New Recurrent Aberration Leading to Partial Monosomy 7q and Trisomy 11q in Acute Myeloid Leukemia

Unbalanced Translocation der(7)t(7q;11q): A New Recurrent Aberration Leading to Partial Monosomy... Unbalanced translocations, which are created if one of the two derivative chromosomes is lost, often result in the loss or gain of chromosomal material rather than the formation of fusion genes in hematological malignancies [1]. They are usually part of complex karyotypes, diagnostically nonspecific and related to disease progression, although some of them seem to be a recurrent and primary anomaly [2,3]. Recently, unbalanced translocations involving chromosome 11, such as der(18)t(11;18)(q13;q21.1) and der(7)t(7;11)(q31;q14), have been reported in acute myeloid leukemia (AML) [4,5]. These translocations occurred as a sole abnormality at diagnosis, and resulted in partial trisomy 11q including three copies of the MLL gene at 11q23. Here, we describe a new case of AML with der(7)t(7q;11q), which led to partial monosomy 7q and partial trisomy 11q including MLL. A 79-year-old Vietnamese male was admitted because of anemia. He had no history of chemoradiotherapy. Peripheral blood showed Hb 7.0 g/dl, PLT 44 × 109/l and WBC 18.5 × 109/l with 25% myeloblasts, 6% myelocytes, 16% metamyelocytes, 5% band forms, 24% segmented neutrophils, 1% basophils, 12% monocytes and 11% lymphocytes. Bone marrow was hypercellular with 22.1% myeloblasts, 66.2% myeloid cells and 0.8% erythroblasts. Blasts were positive for myeloperoxidase staining and immunophenotypically http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Unbalanced Translocation der(7)t(7q;11q): A New Recurrent Aberration Leading to Partial Monosomy 7q and Trisomy 11q in Acute Myeloid Leukemia

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References (11)

Publisher
Karger
Copyright
© 2014 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000358188
Publisher site
See Article on Publisher Site

Abstract

Unbalanced translocations, which are created if one of the two derivative chromosomes is lost, often result in the loss or gain of chromosomal material rather than the formation of fusion genes in hematological malignancies [1]. They are usually part of complex karyotypes, diagnostically nonspecific and related to disease progression, although some of them seem to be a recurrent and primary anomaly [2,3]. Recently, unbalanced translocations involving chromosome 11, such as der(18)t(11;18)(q13;q21.1) and der(7)t(7;11)(q31;q14), have been reported in acute myeloid leukemia (AML) [4,5]. These translocations occurred as a sole abnormality at diagnosis, and resulted in partial trisomy 11q including three copies of the MLL gene at 11q23. Here, we describe a new case of AML with der(7)t(7q;11q), which led to partial monosomy 7q and partial trisomy 11q including MLL. A 79-year-old Vietnamese male was admitted because of anemia. He had no history of chemoradiotherapy. Peripheral blood showed Hb 7.0 g/dl, PLT 44 × 109/l and WBC 18.5 × 109/l with 25% myeloblasts, 6% myelocytes, 16% metamyelocytes, 5% band forms, 24% segmented neutrophils, 1% basophils, 12% monocytes and 11% lymphocytes. Bone marrow was hypercellular with 22.1% myeloblasts, 66.2% myeloid cells and 0.8% erythroblasts. Blasts were positive for myeloperoxidase staining and immunophenotypically

Journal

Acta Haematologica – Karger

Published: Jan 1, 2014

Keywords: Acute myeloid leukemia; Chromosome aberrations

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