Access the full text.
Sign up today, get DeepDyve free for 14 days.
Xin-chao Wang, A. Ghio, Funmei Yang, Kevin Dolan, M. Garrick, C. Piantadosi (2002)
Iron uptake and Nramp2/DMT1/DCT1 in human bronchial epithelial cells.American journal of physiology. Lung cellular and molecular physiology, 282 5
P. Nicolson, M. Doherty, S. Cooper, J. Neilson (2013)
Inhalation as a Source of Iron in Secondary Iron OverloadActa Haematologica, 130
E. Heilig, K. Thompson, R. Molina, A. Ivanov, J. Brain, M. Wessling-Resnick (2006)
Manganese and iron transport across pulmonary epithelium.American journal of physiology. Lung cellular and molecular physiology, 290 6
Funmei Yang, D. Haile, Xin-chao Wang, L. Dailey, J. Stonehuerner, A. Ghio (2005)
Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung.American journal of physiology. Lung cellular and molecular physiology, 289 1
I read with interest the case report by Nicolson et al. [1] describing a patient with secondary iron overload following inhalation of iron. Iron uptake by the lung with systemic translocation is supported by prior rodent investigations [2]. The expression of proteins which participate in iron import, export, storage, and transport can be identified among cells resident in the lung, including the respiratory epithelial cell (e.g. divalent metal transporter 1, ferroportin 1, ferritin, and transferrin and its receptor, respectively) [3]. However, for the uptake of inhaled iron with systemic translocation to be realized, ferroportin 1 (the major iron exporter currently recognized) would have to be positioned at the basilar aspect of the respiratory epithelial cell (toward the basement membrane). While ferroportin 1 has been identified in the respiratory epithelial cell, this protein localizes more to the apical surface (toward the airways and alveolar lumen). Such localization implies that iron is both imported and released at the airways and alveolar lumen rather than toward any vascular structure, which might distribute the metal systemically [4]. The specific positioning of ferroportin 1 at the apical membrane of the respiratory epithelial cell suggests that iron uptake with systemic translocation is not a function for which the lung was designed. Iron overload following inhalation of the metal would accordingly be an infrequent event.
Acta Haematologica – Karger
Published: Jan 1, 2013
Keywords: Iron overload and/or its evaluation; Iron; Iron absorption
You can share this free article with as many people as you like with the url below! We hope you enjoy this feature!
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.