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Acta Cytologica Fine Needle Aspiration Diagnosis of Combined Hepatocellular Carcinoma and Cholangiocarcinoma A Case Report David Gibbons, M.D., and Antonio de las Morenas, M.D. BACKGROUND: The finding of a dual cellular popula- possibility of a combined hepatocellular carcinoma and tion in a liver fine needle aspirate, in the appropriate clin- cholangiocarcinoma and is unlikely to represent metasta- ical context, raises many tic disease. This variant of differential diagnoses, in- hepatocellular carcinoma is This entity should be considered cluding combined hepatocel- rare and constitutes 1–5% of lular carcinoma and cholan- primary liver carcinomas. It when a careful and meticulous giocarcinoma, a relatively is important to make this di- evaluation...demonstrates a dual rare form of primary liver agnosis and to separate this carcinoma. tumor from the usual hepato- population of cells in a liver CASE: A hepatitis C– cellular carcinoma and aspirate.... positive patient with cirrho- metastatic carcinoma, since sis and rapidly worsening it may give rise to pure liver failure underwent fine needle aspiration of two ra- cholangiocarcinomatous metastatic deposits, adding diologically detected liver masses. Abundant material to the diagnostic difficulties. (Acta Cytol 1997;41:1269– composed of two cell populations, one typical of hepato- 1272) cellular carcinoma and one with features
Acta Cytologica – Karger
Published: Jan 1, 2011
Keywords: liver neoplasms; hepatocellular carcinoma; cholangiocarcinoma
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