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E DITORIAL Acta Cytologica The Journal of Clinical Cytology and Cytopathology New Diagnostic Techniques Applicable to Fine N eedle Aspirates With the introduction of neoadjuvant therapy in the emerged as valuable diagnostic adjuncts, especially treatment of various malignancies, there is a de- in the diagnosis of musculoskeletal tumors and se- mand for correct pretreatment diagnosis. When fine lected non-Hodgkin’s lymphomas. A number of needle aspiration and cytodiagnosis are considered soft tissue sarcoma entities have been found to ex- to be the optimal diagnostic method before the start press diagnostic chromosomal aberrations (Table I). of treatment, the cytodiagnosis must equal that of a Chromosomal analysis is possible to perform on histopathologic examination. Chemotherapy com- fine needle aspirates, although the success rate is 1,2 binations are different for different malignancies, less than that with analysis of tissue samples. Flu- and in case of preoperative radiotherapy, the thera- orescence in situ hybridization (FISH) is better suit- py might be successful enough to make a specific ed to aspirate smears and exfoliative specimens. histologic type diagnosis difficult or impossible on As the genes involved in various diagnostic translo- histopathologic examination of the operative speci- cations have been identified, the possibility of per- men.
Acta Cytologica – Karger
Published: Jan 1, 2011
Keywords: aspiration biopsy; diagnostic techniques and procedures; laboratory diagnosis
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