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Acta Cytologica Basement Membrane Material (Hyaline Globules) in Synovial Sarcoma A Case Report with Description of a Potential Diagnostic Pitfall Muralee Dharan, M.D., M.I.A.C., Dan Nachtigal, M.D., Gabriel Rosen, M.D., F.A.C.S., Joseph Honigman, M.D., and Rafael Luboshitzky, M.D. BACKGROUND: Synovial sarcoma (SS), a malignant chemical and ultrastructural studies, proved it to be a mesenchymal tumor, has a biphasic growth pattern char- typical SS with copious basement membrane accumula- acteristically. Histologically and cytologically the tumor tions. can pose diagnostic difficul- CONCLUSION: The cyto- ty when the epithelial com- logic appearance of SS can ponent is predominant. be confusing. However, a A noteworthy feature of this CASE REPORT: A 22- false diagnosis may be tumor, in addition to its year-old female presented avoided if adequate needle cervical location, was the with a rapidly enlarging sampling is ensured and mass on the lower left side of clinical correlation consid- prominent accumulation of the neck. Fine needle aspira- ered. (Acta Cytol 1998;42: extracellular BM material, tion of the tumor yielded 791–795) abundant, discohesive collagen IV and laminin, which, round-oval cells mingled Keywords: sarcoma, syn- on FNA, appeared as hyaline glob- with amorphous hyaline ovial; basement mem- material, raising a suspicion ules. brane; hyaline
Acta Cytologica – Karger
Published: Jan 1, 2011
Keywords: sarcoma, synovial; basement membrane; hyaline globules
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