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Acta Cytologica Utility of the in Situ Detection of HPV in Pap Smears Diagnosed as Within Normal Limits Geetha Menezes, M.D., Elizabeth Euscher, M.D., Brigitte Schwartz, C.T.(IAC), C.T.(ASCP), Francisco Catania, M.D., Jeffrey Chancellor, M.D., and Gerard J. Nuovo, M.D. OBJECTIVE: To determine the clinical significance in was in situ hybridization positive, and eight were HC normal Pap smears of HPV detection as determined by positive; six (67%) of these women developed SIL on TM Hybrid Capture (HC) and follow-up. In the 37 Pap in situ hybridization analy- smears in high-risk women ses. still within normal limits A woman with a Pap smear within STUDY DESIGN: We stud- after manual rescreening, ied 135 consecutive Pap HPV was detected in 2% by normal limits that is negative for smears as well as 46 other in situ hybridization and HPV by in situ hybridization has a smears from high-risk pa- 46% by HC; 6% of the HC- very low risk of dysplasia, even if the tients each initially diag- positive women developed nosed as within normal lim- SIL on follow-up. HC test is positive. its. CONCLUSION: In situ hy- RESULTS: The 135 “nor- bridization rarely detects mal” Pap smears were re- HPV
Acta Cytologica – Karger
Published: Jan 1, 2011
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