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GYNECOLOGIC CYTOPATHOLOGY Acta Cytologica CIN 2/3 and Cervical Cancer After an ASCUS Pap Smear A 7-Year, Prospective Study of the Norwegian Population-Based, Coordinated Screening Program Jan F. Nygård, B.Sc., B.A., Torill Sauer, M.D., Ph.D., F.I.A.C., Finn Egil Skjeldestad, M.D., Ph.D., Gry Baadstrand Skare, B.Sc., and Steinar Østerbø Thoresen, M.D., Ph.D., M.I.A.C. OBJECTIVE: To estimate the risk of being diagnosed a history of CIN 2/3 or ICC, the study population con- with cervical intraepithelial neoplasia (CIN) 2/3 or inva- sisted of women 25–69 years of age with a normal sive cervical cancer (ICC) (n=526,661) or ASCUS based on diagnostic and Pap smear (n = 10,037) in screening procedures per- 1995–1996. Risk estimates ASCUS defines a cytologic group of formed after a diagnosis of were calculated by logistic patients who either may have or atypical squamous cells of and parametric survival re- undetermined significance gression. will develop CIN.... (ASCUS) and to compare RESULTS: Within 7 years of this risk to that in women an ASCUS smear, 1,017 with a normal Pap smears. women (10.1%) were diagnosed with CIN 2/3 and 62 STUDY DESIGN: A 7-year, prospective, cohort study (0.62%) with ICC. Women with an ASCUS index Pap was performed in the
Acta Cytologica – Karger
Published: Jan 1, 2011
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