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Application of Proteomic Technologies to Cytologic Specimens

Application of Proteomic Technologies to Cytologic Specimens MOLECULAR TECHNIQUES ACTA CYTOLOGICA The Journal of Clinical Cytology and Cytopathology Application of Proteomic Technologies to Cytologic Specimens A Review Cesar Angeletti, M.D., Ph.D. With the increasing use of molecular biology techniques Cytopathology, although initially conceived as a in routine pathology practice, it seems reasonable that screening tool, has increasingly gained a more pri- their application to cytologic specimens will become pop- mary role in the definitive diagnosis of neoplastic ular in the near future. Pro- and nonneoplastic dis- teomics is a novel area of re- ease. This phenomenon search that involves the may be the result of not Proteomics can provide information global analysis of tissue pro- only the popularization of that transcriptional analyses teins using diverse technolo- fine needle aspiration gies, such as 2-D gel elec- (FNA) biopsy as a routine cannot.... trophoresis, mass spectrom- diagnostic test but also the etry and bioinformatics. This application of ancillary review discusses recent ap- tools, which include im- plications of proteomic analysis to cytologic specimens as munohistochemistry (IHC), electron microscopy well as its potential in the diagnosis of neoplastic and (EM), nucleic acid technologies and cytogenetic nonneoplastic disease. (Acta Cytol 2003;47:535–544) techniques. Among these, IHC is the one used most http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Cytologica Karger

Application of Proteomic Technologies to Cytologic Specimens

Acta Cytologica , Volume 47 (4): 10 – Jan 1, 2011

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References (80)

Publisher
Karger
Copyright
© 2011 S. Karger AG, Basel
ISSN
0001-5547
eISSN
1938-2650
DOI
10.1159/000326565
Publisher site
See Article on Publisher Site

Abstract

MOLECULAR TECHNIQUES ACTA CYTOLOGICA The Journal of Clinical Cytology and Cytopathology Application of Proteomic Technologies to Cytologic Specimens A Review Cesar Angeletti, M.D., Ph.D. With the increasing use of molecular biology techniques Cytopathology, although initially conceived as a in routine pathology practice, it seems reasonable that screening tool, has increasingly gained a more pri- their application to cytologic specimens will become pop- mary role in the definitive diagnosis of neoplastic ular in the near future. Pro- and nonneoplastic dis- teomics is a novel area of re- ease. This phenomenon search that involves the may be the result of not Proteomics can provide information global analysis of tissue pro- only the popularization of that transcriptional analyses teins using diverse technolo- fine needle aspiration gies, such as 2-D gel elec- (FNA) biopsy as a routine cannot.... trophoresis, mass spectrom- diagnostic test but also the etry and bioinformatics. This application of ancillary review discusses recent ap- tools, which include im- plications of proteomic analysis to cytologic specimens as munohistochemistry (IHC), electron microscopy well as its potential in the diagnosis of neoplastic and (EM), nucleic acid technologies and cytogenetic nonneoplastic disease. (Acta Cytol 2003;47:535–544) techniques. Among these, IHC is the one used most

Journal

Acta CytologicaKarger

Published: Jan 1, 2011

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