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Fine Needle Aspiration Biopsy of Mixed Medullary-Follicular Thyroid Carcinoma

Fine Needle Aspiration Biopsy of Mixed Medullary-Follicular Thyroid Carcinoma Acta Cytologica Fine Needle Aspiration Biopsy of Mixed Medullary-Follicular Thyroid Carcinoma A Report of Two Cases Jaroslava Dusková, ˇ M.D., C.Sci., F.I.A.C., Dana Janotová, M.D., Eva Svobodová, M.D., Zdenek Novák, ˇ M.D., C.Sci., and Pavel Tretiník, M.D., M.I.A.C. BACKGROUND: Mixed differentiated thyroid carcino- carcinoma was established after a complex histologic in- mas are rare tumors, difficult to recognize on fine needle vestigation. The tumor was encapsulated, with partly aspiration biopsy (FNAB). microfollicular architecture. Most cases are diagnosed Immunohistochemistry was only after histologic investi- positive for both calcitonin gation. At the FNAB level, correct and thyreoglobulin. Electron CASES: The cases entailed microscopy from the formol- identification of the medullary two cytologic samples and a paraffin block found neurose- component in a mixed tumor is of thyroidectomy specimen. cretory granules in many Two FNAB thyroidectomy cells. The patient was well crucial importance, leading to specimens from a 60-year-old one year after the operation. one-step, radical surgery. man presenting with a soli- One FNAB and thyroidecto- tary thyroid nodule (case 1) my specimen from a 47-year- were investigated. Both cyto- old woman with long-treated logic samples were referred as atypical, with a mixture of lymphoplasmocellular thyroiditis (case 2) was investi- features indicating http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Cytologica Karger

Fine Needle Aspiration Biopsy of Mixed Medullary-Follicular Thyroid Carcinoma

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References (25)

Publisher
Karger
Copyright
© 2011 S. Karger AG, Basel
ISSN
0001-5547
eISSN
1938-2650
DOI
10.1159/000326478
Publisher site
See Article on Publisher Site

Abstract

Acta Cytologica Fine Needle Aspiration Biopsy of Mixed Medullary-Follicular Thyroid Carcinoma A Report of Two Cases Jaroslava Dusková, ˇ M.D., C.Sci., F.I.A.C., Dana Janotová, M.D., Eva Svobodová, M.D., Zdenek Novák, ˇ M.D., C.Sci., and Pavel Tretiník, M.D., M.I.A.C. BACKGROUND: Mixed differentiated thyroid carcino- carcinoma was established after a complex histologic in- mas are rare tumors, difficult to recognize on fine needle vestigation. The tumor was encapsulated, with partly aspiration biopsy (FNAB). microfollicular architecture. Most cases are diagnosed Immunohistochemistry was only after histologic investi- positive for both calcitonin gation. At the FNAB level, correct and thyreoglobulin. Electron CASES: The cases entailed microscopy from the formol- identification of the medullary two cytologic samples and a paraffin block found neurose- component in a mixed tumor is of thyroidectomy specimen. cretory granules in many Two FNAB thyroidectomy cells. The patient was well crucial importance, leading to specimens from a 60-year-old one year after the operation. one-step, radical surgery. man presenting with a soli- One FNAB and thyroidecto- tary thyroid nodule (case 1) my specimen from a 47-year- were investigated. Both cyto- old woman with long-treated logic samples were referred as atypical, with a mixture of lymphoplasmocellular thyroiditis (case 2) was investi- features indicating

Journal

Acta Cytologica – Karger

Published: Jan 1, 2011

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