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RhabdomyosarcomaActa Cytologica, 44
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Acta Cytologica Cytologic Diagnosis of Rhabdomyosarcoma in a Child with a Pleural Effusion A Case Report Paul Theunissen, Ph.D., M.D., Martin Cremers, C.T.(IAC), Syb van der Meer, Ph.D., M.D., Freek Bot, Ph.D., M.D., and Johannes Bras, Ph.D., M.D. BACKGROUND: A pleural effusion in children is usu- quent computed tomography revealed a mass above the ally caused by infectious diseases; malignant effusion is diaphragm, which was biopsied. Histologic examination very uncommon. In a case of of a needle biopsy specimen a malignant effusion in a confirmed the diagnosis of child, a pleura-based metas- rhabdomyosarcoma. Molecu- Since chromosomal translocations tasis of a neoplasm with a lar examination revealed a are rarely associated with the more typically high prevalence in PAX3-FKHR fusion tran- childhood has to be consid- script specific to the alveolar commonly occurring embryonal ered. Examples are neuro- type of rhabdomyosarcoma. histology, tissue examination is blastoma, nephroblastoma, CONCLUSION: This case Wilms’ tumor, hepatoblas- illustrates the usefulness of necessary in most cases of RMS. toma, malignant germ cell immunocytochemistry on tumor and rhabdomyosarco- cell block preparations in di- ma. agnosing difficult cases of effusion cytology. (Acta Cytol CASE: A 4-year old boy presented with a unilateral pleu- 2004;48:249–253) ral effusion. Cytologic
Acta Cytologica – Karger
Published: Jan 1, 2011
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