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Acta Cytologica Cytologic Features of Functioning Stromal Cells in a Yolk Sac Tumor of the Ovary A Case Report Fumio Horiuchi, C.T., C.F.I.A.C., Yuichiro Nagai, M.D., Aki Kawamura, C.T.(IAC), Takashi Nikaido, M.D., Akira Mitsuhashi, M.D., Naotake Tanaka, M.D., Kiyomi Suzuka, M.D., and Hiroshi Ishikura, M.D. BACKGROUND: Functioning stromal cells are some- CONCLUSION: Because functioning stromal cells may times seen in primary and metastatic ovarian neoplasms. unexpectedly induce hormonal effects in a variety of However, the cytologic fea- ovarian tumors, it is impor- tures of functioning stromal tant to identify such cells in cells have been described cytologic specimens. (Acta The identification of luteinized-type, only rarely. Cytol 2004;48:83–86) functioning stromal cells is of great CASE: A 19-year-old wom- an had an α-fetoprotein– Keywords: stromal cells, importance in routine cytologic producing ovarian yolk sac ovarian cancer, yolk sac practice.... tumor with functioning stro- tumor, imprint cytology. ma. Her preoperative serum testosterone level was elevat- Specialized ovarian stro- ed. Imprint cytology showed that the functioning stromal mal cells can differentiate into hormone-producing cells had centrally located nuclei with low nuclear/ cells, such as theca cells, which can further trans- cytoplasmic ratios. Occasionally these cells had vacuolat- form into luteinized cells. Ovarian stromal
Acta Cytologica – Karger
Published: Jan 1, 2011
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