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TECHNIQUE Diagnostic Parameters in Liquid-Based Cervical Cytology Using a Coagulant Suspension Fixative Mathilde E. Boon, M.D., Ph.D., F.I.A.C., Elisabeth Ouwerkerk-Noordam, Albert J. H. Suurmeijer, M.D., Ph.D., and Lambrecht P. Kok, Ph.D. Objective fact that the cells on the Papspin slide were no longer pres- To evaluate in detail the morphology of cervical cell samples ent in diagnostic streaks posed a problem only in the case of suspended in the coagulant fixative BoonFix (Finetec, follicular cervicitis. Tokyo, Japan) in liquid-based Papspin slides (Thermo Conclusion Shandon, Pittsburgh, Pennsylvania, U.S.A.) to detect shifts in diagnostic parameters for infections and neoplasia. The shifts in parameters facilitated the diagnostic process. BoonFix permits the screen- Study Design ing of liquid-based Papspin This histologic fixative, which was Split samples of 1,010 cases slides, which have proven to be were collected. All Papspin well suited to automated neu- developed in Leiden with the aim slides were scanned with neu- ral network scanning. (Acta to replace formalin, also proved to ral network technology. In Cytol 2005;49:513–519) 849 cases the diagnosis was be well suited to cytology. “within normal limits”; in 22 Keywords: cervical cancer, cases it was preneoplasia. In mass screening, neural net- 151 special cases conventional smears
Acta Cytologica – Karger
Published: Jan 1, 2011
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