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C. Moskaluk, M. Stoler (2002)
Agarose Mold Embedding of Cultured Cells for Tissue MicroarraysDiagnostic Molecular Pathology, 11
V. Schneider (2006)
Tissue Microarrays for Testing Molecular Biomarkers of Cervical Intraepithelial NeoplasiaActa Cytologica, 50
(2002)
Keywords: laboratory diagnosis, tissue microarrays, molecular markers
J. Kononen, L. Bubendorf, Anne Kallionimeni, M. Bärlund, P. Schraml, S. Leighton, J. Torhorst, M. Mihatsch, G. Sauter, Olli-P. Kallionimeni (1998)
Tissue microarrays for high-throughput molecular profiling of tumor specimensNature Medicine, 4
H. Battifora (1986)
The multitumor (sausage) tissue block: novel method for immunohistochemical antibody testing.Laboratory investigation; a journal of technical methods and pathology, 55 2
ACTA CYTOLOGICA EDITORIAL The Journal of Clinical Cytology and Cytopathology It has taken a while for tissue microarrays (TMAs) to are manually skilled by training if not by nature. The finally find their way into cytopathology. Twenty most critical factors for TMA include careful selection years ago, Battifora developed a “sausage” technique of tissues, marking the representative areas on the whereby several tissue specimens could be analyzed at original slides and the collection of the tissue blocks a time. The random mixture of different tissues on 1 from the archive. histologic slide appeared most useful for the purpose Despite TMAs’ great promise, many pathologists of antibody testing but was not widely applied. The initially regarded them with considerable skepticism. need to rapidly analyze large numbers of tumors be- It took a few years and a number of studies to demon- came urgent only 12 years later. A greatly increasing strate that clinical-pathologic correlations could reli- number of new candidate molecular markers emerged ably be identified despite the small size of tissue spec- from DNA microarray experiments; that process was imens on TMA. Today, TMAs are a standard tool for fueled by the completion of the sequence of the the
Acta Cytologica – Karger
Published: Jan 1, 2011
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