Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Tissue Microarrays Meet Cytopathology

Tissue Microarrays Meet Cytopathology ACTA CYTOLOGICA EDITORIAL The Journal of Clinical Cytology and Cytopathology It has taken a while for tissue microarrays (TMAs) to are manually skilled by training if not by nature. The finally find their way into cytopathology. Twenty most critical factors for TMA include careful selection years ago, Battifora developed a “sausage” technique of tissues, marking the representative areas on the whereby several tissue specimens could be analyzed at original slides and the collection of the tissue blocks a time. The random mixture of different tissues on 1 from the archive. histologic slide appeared most useful for the purpose Despite TMAs’ great promise, many pathologists of antibody testing but was not widely applied. The initially regarded them with considerable skepticism. need to rapidly analyze large numbers of tumors be- It took a few years and a number of studies to demon- came urgent only 12 years later. A greatly increasing strate that clinical-pathologic correlations could reli- number of new candidate molecular markers emerged ably be identified despite the small size of tissue spec- from DNA microarray experiments; that process was imens on TMA. Today, TMAs are a standard tool for fueled by the completion of the sequence of the the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Cytologica Karger

Tissue Microarrays Meet Cytopathology

Acta Cytologica , Volume 50 (2): 2 – Jan 1, 2011

Loading next page...
 
/lp/karger/tissue-microarrays-meet-cytopathology-o0EtjFJecC

References (5)

Publisher
Karger
Copyright
© 2011 S. Karger AG, Basel
ISSN
0001-5547
eISSN
1938-2650
DOI
10.1159/000325918
Publisher site
See Article on Publisher Site

Abstract

ACTA CYTOLOGICA EDITORIAL The Journal of Clinical Cytology and Cytopathology It has taken a while for tissue microarrays (TMAs) to are manually skilled by training if not by nature. The finally find their way into cytopathology. Twenty most critical factors for TMA include careful selection years ago, Battifora developed a “sausage” technique of tissues, marking the representative areas on the whereby several tissue specimens could be analyzed at original slides and the collection of the tissue blocks a time. The random mixture of different tissues on 1 from the archive. histologic slide appeared most useful for the purpose Despite TMAs’ great promise, many pathologists of antibody testing but was not widely applied. The initially regarded them with considerable skepticism. need to rapidly analyze large numbers of tumors be- It took a few years and a number of studies to demon- came urgent only 12 years later. A greatly increasing strate that clinical-pathologic correlations could reli- number of new candidate molecular markers emerged ably be identified despite the small size of tissue spec- from DNA microarray experiments; that process was imens on TMA. Today, TMAs are a standard tool for fueled by the completion of the sequence of the the

Journal

Acta CytologicaKarger

Published: Jan 1, 2011

There are no references for this article.