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Fine Needle Aspiration Fine Needle Aspiration Cytology and Flow Cytometry in the Diagnosis and Subclassification of Non-Hodgkin’s Lymphoma Based on the World Health Organization Classification Markus Bangerter, M.D., Ph.D., Olaf Brudler, M.D., Bernhard Heinrich, M.D., and Martin Griesshammer, M.D., Ph.D. Objective Conclusion To determine the usefulness of fine needle aspiration cytol- The combination of FNAC and flow cytometry obtained by ogy (FNAC) in combination with flow cytometry on the new FNAC can distinguish between benign and malignant lym- World Health Organization (WHO) classification of ma- phoid infiltrates and support a diagnosis of lymphoma. lignant lymphoma. (Acta Cytol 2007;51:390–398) Study Design Keywords: aspiration cy- Smears and flow cytometry re- tology, fine-needle; flow ports of patients who under- cytometry; lymphoma, The grading of follicular center went both methods at the same non-Hodgkin’s. lymphoma remains one of the time were independently ex- amined. Both methods were most important obstacles in the alignant lymphoma is classified according to the new Mthe most common cytomorphologic diagnosis WHO classification of malig- hematologic malignancy of NHL. nant lymphoma. encountered in the western world. In the United Results States, the incidence of ma- A group of 131 smears were examined. In 89 cases exact di- lignant lymphoma
Acta Cytologica – Karger
Published: Jan 1, 2011
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