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Case Reports Imprint Cytologic Features in Renal Cell Carcinoma Associated with Xp11.2 Translocation/TFE3 Gene Fusion in an Adult A Case Report Tadanori Yamaguchi, C.T., C.M.I.A.C., Naoto Kuroda, M.D., Yoshiaki Imamura, M.D., F.I.A.C., Ondrej Hes, M.D., Takako Kawada, C.T.(IAC), and Keizou Nakayama, C.T.(IAC), D.V.M. Background gene fusion is suspected by imprint cytology even in adult-onset cases, and Adult-onset renal cell carcinoma (RCC) associated with Xp11.2 transloca- cytotechnologists should accurately recognize cytologic findings of this tumor. tion/TFE3 gene fusion is a very rare tumor. To date, there are no reports (Acta Cytol 2009;53:693–697) on immunocytochemical study of the primary tumor. We describe such a case that we diagnosed by immunocytochemistry of imprint cytology mate- Keywords: adult, imprint cytology, renal cell carcinoma, TFE3, rial. Xp11.2 translocation. Case lear cell renal cell carcinoma A 46-year-old man was found to have C(RCC) and papillary RCC ac- We suggest that a definitive diagnosis of a mass in the lower pole of the right count for > 85% of renal cell carci- kidney. Magnetic resonance imaging nomas in adults. However, RCC TFE3-RCC may be possible at the cytologic (MRI) T2-weighted images showed a is very rare in children, but it is level if detailed evaluation of
Acta Cytologica – Karger
Published: Jan 1, 2011
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