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Imprint Cytology of Axillary Lymph Nodes in Breast Carcinoma Following Neoadjuvant Chemotherapy

Imprint Cytology of Axillary Lymph Nodes in Breast Carcinoma Following Neoadjuvant Chemotherapy NONGYNECOLOGIC CYTOPATHOLOGY Imprint Cytology of Axillary Lymph Nodes in Breast Carcinoma Following Neoadjuvant Chemotherapy Aneeth Jegaraj, M.B.B.S., M.S., Dharanipragada Kadambari, M.B.B.S., M.S., Krishnamachari Srinivasan, M.B.B.S., M.S., and Neelaiah Siddaraju, M.D. Objective ly. No statistically significant difference was found with re- To evaluate the efficacy of imprint cytology (IC) in detect- spect to the cellularity of imprints. Sensitivity, specificity ing residual axillary metastasis following neoadjuvant and diagnostic accuracy were 89.1%, 99.1% and 95.4%, chemotherapy (NACT) in order to check its feasibility on respectively. The false positive and negative rates were sentinel nodes in the postther- 0.6% and 4.1%, respectively. apy setting in patients with The positive and negative pre- breast carcinoma. dictive values were 98.3% Our study also emphasized the need and 93.9%, respectively. Study Design for a cautious approach when Conclusion Thirty women on NACT for interpreting imprints with sparse cells locally advanced breast cancer IC is a sensitive, specific and and poorly preserved morphology in were subjected to total mastec- accurate method of detecting tomy with axillary node dissec- the postchemotherapy setting. axillary metastasis in patients tion. Routinely stained im- with down-staged tumors fol- prints from 172 resected nodes lowing chemotherapy. The fact were studied to detect residual http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Cytologica Karger

Imprint Cytology of Axillary Lymph Nodes in Breast Carcinoma Following Neoadjuvant Chemotherapy

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References (29)

Publisher
Karger
Copyright
© 2011 S. Karger AG, Basel
ISSN
0001-5547
eISSN
1938-2650
DOI
10.1159/000325233
Publisher site
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Abstract

NONGYNECOLOGIC CYTOPATHOLOGY Imprint Cytology of Axillary Lymph Nodes in Breast Carcinoma Following Neoadjuvant Chemotherapy Aneeth Jegaraj, M.B.B.S., M.S., Dharanipragada Kadambari, M.B.B.S., M.S., Krishnamachari Srinivasan, M.B.B.S., M.S., and Neelaiah Siddaraju, M.D. Objective ly. No statistically significant difference was found with re- To evaluate the efficacy of imprint cytology (IC) in detect- spect to the cellularity of imprints. Sensitivity, specificity ing residual axillary metastasis following neoadjuvant and diagnostic accuracy were 89.1%, 99.1% and 95.4%, chemotherapy (NACT) in order to check its feasibility on respectively. The false positive and negative rates were sentinel nodes in the postther- 0.6% and 4.1%, respectively. apy setting in patients with The positive and negative pre- breast carcinoma. dictive values were 98.3% Our study also emphasized the need and 93.9%, respectively. Study Design for a cautious approach when Conclusion Thirty women on NACT for interpreting imprints with sparse cells locally advanced breast cancer IC is a sensitive, specific and and poorly preserved morphology in were subjected to total mastec- accurate method of detecting tomy with axillary node dissec- the postchemotherapy setting. axillary metastasis in patients tion. Routinely stained im- with down-staged tumors fol- prints from 172 resected nodes lowing chemotherapy. The fact were studied to detect residual

Journal

Acta Cytologica – Karger

Published: Jan 1, 2011

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