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Cytology Features of Bing-Neel Syndrome

Cytology Features of Bing-Neel Syndrome Letters to the Editors Keywords: cytohistology, liquid-based cytology, p16. (Acta Cytol 2009;53:239–240) Cytology Features of Bing-Neel Syndrome To the Editors: Waldenström’s macroglobulinemia (WM) results Figure 2 Tissue fragment in the original Papanicolaou-stained from neoplastic proliferation of plasmacytoid lympho- thin-layer slide with nuclear blurring in the central part of this cytes, and WM represents the majority of cases under minibiopsy sample. The peripheral nuclei are clearly abnormal and the diagnosis of lymphoplasmacytic lymphoma ac- display nucleolar prominence, highly suggestive for their malignant nature. In short, in our opinion this is a truly false negative ThinPrep cording to the World Health Organization classifica- (× 400). 1 tion. About 25% of WM patients have central nerv- ous system (CNS) complications, such as stroke and neuropathy, and the majority of complications are associated with blood hyperviscosity caused by mono- clonal immunoglubin M. CNS infiltration by malig- or epithelial fragments, we use the cytoblock tech- nant plasmacytoid lymphocytes (Bing-Neel syn- nique to clarify the case, using the valuable diagnostic drome) in patients with WM is a rare entity, and to the material still present in the vial. Figure 2 shows a tis- best of our knowledge there are no cases reported in sue fragment http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Cytologica Karger

Cytology Features of Bing-Neel Syndrome

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References (8)

Publisher
Karger
Copyright
© 2011 S. Karger AG, Basel
ISSN
0001-5547
eISSN
1938-2650
DOI
10.1159/000325135
Publisher site
See Article on Publisher Site

Abstract

Letters to the Editors Keywords: cytohistology, liquid-based cytology, p16. (Acta Cytol 2009;53:239–240) Cytology Features of Bing-Neel Syndrome To the Editors: Waldenström’s macroglobulinemia (WM) results Figure 2 Tissue fragment in the original Papanicolaou-stained from neoplastic proliferation of plasmacytoid lympho- thin-layer slide with nuclear blurring in the central part of this cytes, and WM represents the majority of cases under minibiopsy sample. The peripheral nuclei are clearly abnormal and the diagnosis of lymphoplasmacytic lymphoma ac- display nucleolar prominence, highly suggestive for their malignant nature. In short, in our opinion this is a truly false negative ThinPrep cording to the World Health Organization classifica- (× 400). 1 tion. About 25% of WM patients have central nerv- ous system (CNS) complications, such as stroke and neuropathy, and the majority of complications are associated with blood hyperviscosity caused by mono- clonal immunoglubin M. CNS infiltration by malig- or epithelial fragments, we use the cytoblock tech- nant plasmacytoid lymphocytes (Bing-Neel syn- nique to clarify the case, using the valuable diagnostic drome) in patients with WM is a rare entity, and to the material still present in the vial. Figure 2 shows a tis- best of our knowledge there are no cases reported in sue fragment

Journal

Acta Cytologica – Karger

Published: Jan 1, 2011

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