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Techniques Mutagen Sensitivity in Oral Cancer Patients, Healthy Tobacco Chewers and Controls Beena P. Patel, Ph.D., Pina J. Trivedi, M.Sc., Manisha M. Brahmbhatt, M.Sc., Shilin N. Shukla, M.D., Pankaj M. Shah, M.D., and Sonal R. Bakshi, Ph.D. Objective Conclusion To analyze chromosomal aberrations (CA) as an index of There is a probable risk of oral carcinogenesis in healthy to- DNA damage, to measure DNA repair capability using bacco consumers having higher CA and LTE. Whether the mutagen sensitivity assay and to correlate tobacco exposure deficient DNA repair capacity of oral cancer patients is due with CA. to the disease process or the tobacco exposure needs to be con- firmed with a larger population study. (Acta Cytol 2010; Study Design 54:169–174) Oral cancer patients, healthy tobacco chewers and healthy Keywords: chewing tobac- The present study confirms that (1) tobacco nonusers were studied co, chromosomal aberra- DNA repair capacity is lower in for spontaneous and mutagen- tions, oral cancer, risk as- induced CA. An arbitrary sessment. patients than chewers and controls, unit obtained for lifetime to- (2) patients with higher tobacco bacco exposure (LTE) was ral cancer is important exposure have higher CA, and (3) compared with CA. Oepidemiologically, geo- graphically
Acta Cytologica – Karger
Published: Jan 1, 2011
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