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- Publisher
- Karger
- Copyright
- © 2011 S. Karger AG, Basel
- ISSN
- 0001-5547
- eISSN
- 1938-2650
- DOI
- 10.1159/000324963
- Publisher site
- See Article on Publisher Site
Abstract
NONGYNECOLOGIC CYTOPATHOLOGY Detecting p53 Immunoexpression in Esophageal Mucosa with Exfoliative Cytology in Individuals at Risk for Squamous Cell Carcinoma of the Esophagus Antônio B. Lopes, M.D., Leandro B. Müller, M.D., Roberta Reichert, M.D., Cláudia M. Moraes, M.D., Anderson M. Capra, M.D., João Carlos Prolla, M.D., Ph.D., Ada R. S. Diehl, M.D., Ph.D., Luise Meurer, M.D., Ph.D., Sergio G. Silva de Barros, M.D., Ph.D., and Renato B. Fagundes, M.D., Ph.D. Objective with the RS Balloon immediately followed by upper gas- To determine the prevalence of p53 expression in cytologic trointestinal endoscopy with biopsies of unstained areas after smear collected by the RS Balloon in high-risk individuals, iodine mucosal staining of the esophagus. For each patient, and test its yield in the cytolog- cytologic expression of p53 was ic screening of squamous cell compared with the worst endo- carcinoma of the esophagus scopic biopsy diagnosis and the Our findings suggest that p53 is not a (SCCE). histologic expression of p53. good adjuvant marker to be used in Study Design Results exfoliative cytology in subjects at risk Asymptomatic individuals at One hundred seventy-one in- for SCCE. risk for SCCE underwent dividuals were submitted to esophageal exfoliative cytology the study’s protocol. There From
Journal
Acta Cytologica – Karger
Published: Jan 1, 2011