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Acta haemat. 31: 24-35 (1964). T h e E ffe c ts o f E x o g e n o u s H e p a r i n U p o n t h e N u m b e r a n d M o rp h o lo g y o f B a s o p h ils * By E r n s t T h o n n a r d - N e u m a n n , Washington, D .C . T he substance which causes the metachromasia of tissue mast cell granules was identified by H olmgren and W ilander in 1937 as H eparin (1). In hum an blood basophils heparin-like substances have also been found, though there is still some controversy about their true identity (2, 3, 4). In recent years, several authors have studied the effect o f exogenous heparin upon the num ber of circu lating basophils. Angeli et al. (5) reported an increase in healthy male subjects within two hours after a single injection of heparin ; Braun- steiner a n d T h u m b (6 ) saw' under similar experimental
Acta Haematologica – Karger
Published: Jan 1, 2009
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