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- Publisher
- Karger
- Copyright
- © 1965 S. Karger AG, Basel
- ISSN
- 0001-5792
- eISSN
- 1421-9662
- DOI
- 10.1159/000209525
- Publisher site
- See Article on Publisher Site
Abstract
Acta haemal. 33: 167-177 (1965). From the Department of Biology, St. John’s University Graduate School and the Department of Anatomy, New York Medical College, New York, N. Y. P ro te c tiv e Effects o f E r y th r o p o ie tin A gainst M yleran In d u c e d H em ato d ep ressio n * By P . T. M e d ic i, J . M . H u r s t, and S. J . P il ie r o The similarities between the peripheral hematopoietic effects of x-radiation and those of Myleran and Leukeran were described by E lson (1 ). When Myleran was administered to rats in a rela tively small dose (15 mg/kg) a gradual fall in circulating neutro phils to 10% of the normal value occurred twelve days post treat ment, while larger doses caused an additional decrease in red blood cells and lymphocytes. For this reason, Myleran was said to mimic the myeloid effects of x-radiation (400—600 r). On the other hand, it was found that Leukeran produced a selective and immediate decrease in lymphoid elements, thus mimicking the lymphoid effects of
Journal
Acta Haematologica – Karger
Published: Jan 1, 2009