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Fractionation of Erythropoietin by Selective Membrane Permeability

Fractionation of Erythropoietin by Selective Membrane Permeability Acta haemat. 38: 372 376 (1967) Veterans Administration Hospital and the Medical College of Georgia, Augusta, Ga. F r a c tio n a tio n o f E r y th ro p o ie tin by S elective M e m b ra n e P e rm e a b ility * J . P. L e w is, D o r o t h y A. A l f o r d , C.-S. W r ig h t , E. G a r d n e r , J r . , J . H. R a t h j e n , J r . a n d R. R. M oores Erythropoietin exists in a free and bound form (1, 2). Less than 25% of erythropoietin is normally free and diffusible (3). Most of the urinary erythropoietin seems to be bound to several proteins, and the binding limits the use of chromatography in the purification of the active principle. Erythropoietin has been demonstrated to be somewhat diffusible under certain conditions (4, 5, 6 ) . L e w is et al. (3), working with urine concentrates obtained by flash evaporation, showed that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Fractionation of Erythropoietin by Selective Membrane Permeability

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Publisher
Karger
Copyright
© 1967 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000209038
Publisher site
See Article on Publisher Site

Abstract

Acta haemat. 38: 372 376 (1967) Veterans Administration Hospital and the Medical College of Georgia, Augusta, Ga. F r a c tio n a tio n o f E r y th ro p o ie tin by S elective M e m b ra n e P e rm e a b ility * J . P. L e w is, D o r o t h y A. A l f o r d , C.-S. W r ig h t , E. G a r d n e r , J r . , J . H. R a t h j e n , J r . a n d R. R. M oores Erythropoietin exists in a free and bound form (1, 2). Less than 25% of erythropoietin is normally free and diffusible (3). Most of the urinary erythropoietin seems to be bound to several proteins, and the binding limits the use of chromatography in the purification of the active principle. Erythropoietin has been demonstrated to be somewhat diffusible under certain conditions (4, 5, 6 ) . L e w is et al. (3), working with urine concentrates obtained by flash evaporation, showed that

Journal

Acta Haematologica – Karger

Published: Jan 1, 2009

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