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Acta haemat. 38: 19-33 (1967) The Chester Beatty Research Institute, Institute of Cancer Research; Royal Cancer Hospital, London, and the Department of Pathology, St. Thomas’ Hospital, Medical School, London The Proliferation of Infectious Mononucleosis Lymphocytes in vitro E. H. C o o pe r , A. J . H ale and J. D. M ilton Studies of the proliferation of leucocytes in various circum stances may be expected to yield information about mechanisms of control of leucocyte production. In the course of its mitotic cycle the cell passes through four distinct stages: G1; a stage in which the DNA content is diploid (20) and DNA synthesis has not commenced; S, a stage of replication of the DNA, when the DNA content increases from 2c to 4c (tetraploid) 1 Gg, a period in which the cell nucleus has a 4c DNA content and is awaiting the onset of mitosis; finally mitosis (M). It is convenient to consider that these stages in the division cycle represent clear cut compartments. The relative distribution of cells amongst the compartments provides some information about the proliferative activity of the cell popu lation; far more information can be obtained about proliferation rates when the passage
Acta Haematologica – Karger
Published: Jan 1, 2009
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