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The Proliferation of Infectious Mononucleosis Lymphocytes in vitro

The Proliferation of Infectious Mononucleosis Lymphocytes in vitro Acta haemat. 38: 19-33 (1967) The Chester Beatty Research Institute, Institute of Cancer Research; Royal Cancer Hospital, London, and the Department of Pathology, St. Thomas’ Hospital, Medical School, London The Proliferation of Infectious Mononucleosis Lymphocytes in vitro E. H. C o o pe r , A. J . H ale and J. D. M ilton Studies of the proliferation of leucocytes in various circum­ stances may be expected to yield information about mechanisms of control of leucocyte production. In the course of its mitotic cycle the cell passes through four distinct stages: G1; a stage in which the DNA content is diploid (20) and DNA synthesis has not commenced; S, a stage of replication of the DNA, when the DNA content increases from 2c to 4c (tetraploid) 1 Gg, a period in which the cell nucleus has a 4c DNA content and is awaiting the onset of mitosis; finally mitosis (M). It is convenient to consider that these stages in the division cycle represent clear cut compartments. The relative distribution of cells amongst the compartments provides some information about the proliferative activity of the cell popu­ lation; far more information can be obtained about proliferation rates when the passage http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

The Proliferation of Infectious Mononucleosis Lymphocytes in vitro

Acta Haematologica , Volume 38 (1): 15 – Jan 1, 2009

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Publisher
Karger
Copyright
© 1967 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000208996
Publisher site
See Article on Publisher Site

Abstract

Acta haemat. 38: 19-33 (1967) The Chester Beatty Research Institute, Institute of Cancer Research; Royal Cancer Hospital, London, and the Department of Pathology, St. Thomas’ Hospital, Medical School, London The Proliferation of Infectious Mononucleosis Lymphocytes in vitro E. H. C o o pe r , A. J . H ale and J. D. M ilton Studies of the proliferation of leucocytes in various circum­ stances may be expected to yield information about mechanisms of control of leucocyte production. In the course of its mitotic cycle the cell passes through four distinct stages: G1; a stage in which the DNA content is diploid (20) and DNA synthesis has not commenced; S, a stage of replication of the DNA, when the DNA content increases from 2c to 4c (tetraploid) 1 Gg, a period in which the cell nucleus has a 4c DNA content and is awaiting the onset of mitosis; finally mitosis (M). It is convenient to consider that these stages in the division cycle represent clear cut compartments. The relative distribution of cells amongst the compartments provides some information about the proliferative activity of the cell popu­ lation; far more information can be obtained about proliferation rates when the passage

Journal

Acta HaematologicaKarger

Published: Jan 1, 2009

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