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The Effect of Cytosine Arabinoside on Nucleic Acid Synthesis in Normal and Leukaemic Human Leucocytes in vitro

The Effect of Cytosine Arabinoside on Nucleic Acid Synthesis in Normal and Leukaemic Human... Acta haemat. 41: 321-327 (1969) Department of Medicine, University o f Cambridge, Cambridge The Effect of Cytosine Arabinoside on Nucleic Acid Synthesis in Normal and Leukaemic Human Leucocytes in vitro B. W. B. C h a n Cytosine arabinoside is a synthetic pyrimidine nucleoside. It inhibits replication o f DNA viruses e.g. vaccinia virus [1] an d has in vivo anti-tum our activity against the L1210 mouse leukaemia an d a variety o f rodent leukaemias and lymphomas [2, 3, 4]. Preliminary trials showed it to be a promising new agent in the therapy o f hum an acute leukaemia [5] and further clinical evaluation is currently in progress. This p aper reports the results o f in vitro culture studies on the effects of this drug on DNA and RNA metabolism in hum an leuco­ cytes, including both norm al and leukaemic cells. Materials and Methods Blood cells were obtained from 4 patients and marrow cells from one patient with acute leukaemia. Their cytological type, clinical status and therapeutic history are shown in table I. None o f the patients had been treated with cytosine arabinoside. In patients 2, 3, 4 and 5 the only primitive cells in http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

The Effect of Cytosine Arabinoside on Nucleic Acid Synthesis in Normal and Leukaemic Human Leucocytes in vitro

Chan, B.W.B.
Acta Haematologica , Volume 41 (6): 7 – Jan 1, 2009
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Publisher
Karger
Copyright
© 1969 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000208868
Publisher site
See Article on Publisher Site

Abstract

Acta haemat. 41: 321-327 (1969) Department of Medicine, University o f Cambridge, Cambridge The Effect of Cytosine Arabinoside on Nucleic Acid Synthesis in Normal and Leukaemic Human Leucocytes in vitro B. W. B. C h a n Cytosine arabinoside is a synthetic pyrimidine nucleoside. It inhibits replication o f DNA viruses e.g. vaccinia virus [1] an d has in vivo anti-tum our activity against the L1210 mouse leukaemia an d a variety o f rodent leukaemias and lymphomas [2, 3, 4]. Preliminary trials showed it to be a promising new agent in the therapy o f hum an acute leukaemia [5] and further clinical evaluation is currently in progress. This p aper reports the results o f in vitro culture studies on the effects of this drug on DNA and RNA metabolism in hum an leuco­ cytes, including both norm al and leukaemic cells. Materials and Methods Blood cells were obtained from 4 patients and marrow cells from one patient with acute leukaemia. Their cytological type, clinical status and therapeutic history are shown in table I. None o f the patients had been treated with cytosine arabinoside. In patients 2, 3, 4 and 5 the only primitive cells in

Journal

Acta Haematologica – Karger

Published: Jan 1, 2009

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