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/lp/karger/the-urinary-excretion-of-haemoglobin-in-the-isolated-normothermic-RUBSjmr3c4
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- Publisher
- Karger
- Copyright
- © 1972 S. Karger AG, Basel
- ISSN
- 0001-5792
- eISSN
- 1421-9662
- DOI
- 10.1159/000208501
- Publisher site
- See Article on Publisher Site
Abstract
The isolated kidney handles haemoglobin in the same manner as the kidney in vivo. There is no excretion of haemoglobin when the haemoglobin-binding capacity is not saturated. When this is done and a free plasma haemoglobin level exists, the clearance of free haemoglobin had an average value of 3.24 ± 2.92 ml/min. The glomerular clearance ratio of haemoglobin averaged 0.10 ± 0.06. The calculated rate of tubular reabsorption of haemoglobin was 2.06 ± 3.12 mg/min. The graphic relationship between urinary excretion and plasma levels of free haemoglobin was linear. The theoretical plasma level above which haemoglobinuria occurred was 64.0 ± 35.2 mg%. These last two data are more suggestive of tubular reabsorptive activity than the calculated values.
Journal
Acta Haematologica – Karger
Published: Jan 1, 2009
Keywords: Haemolysis; Haptoglobin; Plasma haemoglobin; Dog kidney; Haemoglobinaemia; Haemoglobinuria