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L-Asparaginase Effect on the Erythrocyte-Immunoglobulin Binding in Acquired Hemolytic Anemia

L-Asparaginase Effect on the Erythrocyte-Immunoglobulin Binding in Acquired Hemolytic Anemia The possibility of direct release of immunoglobulin from the erythrocyte surfaces due to the break of the erythrocyte-immunoglobulin binding after the i.v. administration of L-asparaginase has been shown in patients with acquired hemolytic anemia of IgG and IgA type. These studies were carried out by means of immunofluorescent observation, the determination ofthe immunoglobulin content in the serum, and the direct antiglobulin test. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

L-Asparaginase Effect on the Erythrocyte-Immunoglobulin Binding in Acquired Hemolytic Anemia

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Publisher
Karger
Copyright
© 1972 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000208498
Publisher site
See Article on Publisher Site

Abstract

The possibility of direct release of immunoglobulin from the erythrocyte surfaces due to the break of the erythrocyte-immunoglobulin binding after the i.v. administration of L-asparaginase has been shown in patients with acquired hemolytic anemia of IgG and IgA type. These studies were carried out by means of immunofluorescent observation, the determination ofthe immunoglobulin content in the serum, and the direct antiglobulin test.

Journal

Acta HaematologicaKarger

Published: Jan 1, 2009

Keywords: Immunoglobulins; Asparaginase; Erythrocyte antibodies; Hemolytic anemia; Immunofluorescence

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