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Iron Release in the Reticuloendothelial Cells of the Spleen after Red Cell Damage

Iron Release in the Reticuloendothelial Cells of the Spleen after Red Cell Damage Equivalent hemolysis was produced, after 24 h, in adult albino rats, by the intracardiac injection of copper sulphate, phenylhydrazine and antiserum. The erythrophagocytic count was done on sections of the spleen and compared with the release of Perl’s within the splenic reticuloendothelial cells (REC). From the results obtained it is concluded that iron is released within the splenic REC after erythrophagocytosis while the hemoglobin spilt directly into the plasma is not processed by these cells. The activity of the REC varies with the agent, copper sulphate giving rise to a rapid release of iron whereas phenylhydrazine and antiserum produce a slower activity. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Iron Release in the Reticuloendothelial Cells of the Spleen after Red Cell Damage

Acta Haematologica , Volume 48 (6): 6 – Jan 1, 2009

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Publisher
Karger
Copyright
© 1972 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000208484
Publisher site
See Article on Publisher Site

Abstract

Equivalent hemolysis was produced, after 24 h, in adult albino rats, by the intracardiac injection of copper sulphate, phenylhydrazine and antiserum. The erythrophagocytic count was done on sections of the spleen and compared with the release of Perl’s within the splenic reticuloendothelial cells (REC). From the results obtained it is concluded that iron is released within the splenic REC after erythrophagocytosis while the hemoglobin spilt directly into the plasma is not processed by these cells. The activity of the REC varies with the agent, copper sulphate giving rise to a rapid release of iron whereas phenylhydrazine and antiserum produce a slower activity.

Journal

Acta HaematologicaKarger

Published: Jan 1, 2009

Keywords: Erythrophagocytosis; Haemoglobin; Haemoglobin iron; Haemolysis; Splenic iron

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