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Diagnosis of Meningeal Leukemia in Acute Childhood Lymphocytic Leukemia with Periodic Acid-Schiff Reaction of Cytocentrifuged Liquor

Diagnosis of Meningeal Leukemia in Acute Childhood Lymphocytic Leukemia with Periodic Acid-Schiff... The cerebrospinal fluid (CSF) of 22 consecutive untreated children with acute lymphocytic leukemia who entered total study VII from September to December 1971 at St. Jude Children’s Research Hospital was examined. Four patients had periodic acid-Schiff (PAS)-positive, Sudan black B- and peroxidase-negative lymphoblasts in the CSF at diagnosis. Two of the 4 developed meningeal leukemia 3 and 5 months following diagnosis. None revealed pleocytosis and/or detectable atypical cells on a Wright-stained smear of CSF sediment at diagnosis. Two patients had no more detectable PAS-positive lymphoblasts after ‘prophylactic’ central nervous system (CNS) radiotherapy. They are in continuous complete remission for 9 and 10 months. The recognition of a small number of CSF-abnormal cells with PAS reaction and the differentiation of blasts from inflammatory cells may allow an earlier diagnosis and treatment of CNS involvement in childhood acute lymphocytic leukemia. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Diagnosis of Meningeal Leukemia in Acute Childhood Lymphocytic Leukemia with Periodic Acid-Schiff Reaction of Cytocentrifuged Liquor

Acta Haematologica , Volume 49 (3): 5 – Jan 1, 2009

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Publisher
Karger
Copyright
© 1973 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000208404
Publisher site
See Article on Publisher Site

Abstract

The cerebrospinal fluid (CSF) of 22 consecutive untreated children with acute lymphocytic leukemia who entered total study VII from September to December 1971 at St. Jude Children’s Research Hospital was examined. Four patients had periodic acid-Schiff (PAS)-positive, Sudan black B- and peroxidase-negative lymphoblasts in the CSF at diagnosis. Two of the 4 developed meningeal leukemia 3 and 5 months following diagnosis. None revealed pleocytosis and/or detectable atypical cells on a Wright-stained smear of CSF sediment at diagnosis. Two patients had no more detectable PAS-positive lymphoblasts after ‘prophylactic’ central nervous system (CNS) radiotherapy. They are in continuous complete remission for 9 and 10 months. The recognition of a small number of CSF-abnormal cells with PAS reaction and the differentiation of blasts from inflammatory cells may allow an earlier diagnosis and treatment of CNS involvement in childhood acute lymphocytic leukemia.

Journal

Acta HaematologicaKarger

Published: Jan 1, 2009

Keywords: Childhood leukemia; Meningeal leukemia; PAS reaction; Acute lymphocytic leukemia

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