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The Relevance of Immune Reactions in Acute Favism

The Relevance of Immune Reactions in Acute Favism In fava bean extracts the proteins were separated and characterized by gel filtration on Sephadex G-25 columns, cellogel electrophoresis and analytical ultracentrifugation. The dried extract and its chromatographic fractions were used to detect serum antibodies to fava beans by passive haemagglutination tests. 75 patients affected by acute favism were studied by this method. Haemagglutination tests were positive in 5 patients (6.6%) at the onset of the haemolytic crisis but a rapid fall of the titres was observed in the subsequent days, β<sub>1</sub>c/β<sub>1A</sub> and immunoglobulin levels showed no significant changes. Our results do not support the view that hypersensitivity to fava bean may be involved in the haemolysis of acute favism. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

The Relevance of Immune Reactions in Acute Favism

Fiorelli, G.; Podda, M.; Corrias, A.; Fargion, S.
Acta Haematologica , Volume 51 (4): 8 – Jan 1, 1974
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Publisher
Karger
Copyright
© 1974 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000208296
Publisher site
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Abstract

In fava bean extracts the proteins were separated and characterized by gel filtration on Sephadex G-25 columns, cellogel electrophoresis and analytical ultracentrifugation. The dried extract and its chromatographic fractions were used to detect serum antibodies to fava beans by passive haemagglutination tests. 75 patients affected by acute favism were studied by this method. Haemagglutination tests were positive in 5 patients (6.6%) at the onset of the haemolytic crisis but a rapid fall of the titres was observed in the subsequent days, β<sub>1</sub>c/β<sub>1A</sub> and immunoglobulin levels showed no significant changes. Our results do not support the view that hypersensitivity to fava bean may be involved in the haemolysis of acute favism.

Journal

Acta Haematologica – Karger

Published: Jan 1, 1974

Keywords: Antibodies in favism; Fava bean extract; Favism; Gel filtration

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