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/lp/karger/pha-response-of-blood-and-lymph-node-lymphocytes-in-vitro-in-malignant-qFMcq0RtSV
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- Publisher
- Karger
- Copyright
- © 1974 S. Karger AG, Basel
- ISSN
- 0001-5792
- eISSN
- 1421-9662
- DOI
- 10.1159/000208279
- Publisher site
- See Article on Publisher Site
Abstract
In vitro blastic phytohaemagglutinin (PHA) transformation of blood and lymph node lymphocytes from cases of lymphadenitis, malignant lymphomas, and chronic lymphocytic leukaemia (CLL) has been studied. In lymphosarcoma and CLL the percentage of PHA-transformed lymph node lymphocytes was low, thus suggesting that such lymphocytes are of the B type. In Hodgkin’s disease, blood and lymph node lymphocytes gave PHA transformation nearly as high as in controls; this suggests that T lymphocytes are not necessarily involved in Hodgkin’s disease.
Journal
Acta Haematologica – Karger
Published: Jan 1, 1974
Keywords: Lymphocyte types (B, T); Malignant lymphomas; Phytohaemagglutinin; Lymphocyte transformation; Lymphadenitis