Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Further Investigations of the γ-Chain in a Ghanaian Adult, Homozygous for Hereditary Persistence of Fetal Haemoglobin

Further Investigations of the γ-Chain in a Ghanaian Adult, Homozygous for Hereditary Persistence... The γ chain in a Ghanaian homozygous for hereditary persistence of fetal haemoglobin was considered to be of the G<sub>γ</sub>type on the basis of the amino acid analysis of <sub>γ</sub>Tp XIV (<sub>γ</sub>133–144) of the Hb F of this subject [1]. Recently, the sequence of residues <sub>γ</sub>134–137 of the <sub>γ</sub>-chain of this subject was determined and found to contain some alanine at position <sub>γ</sub>136. It is therefore of the G<sub>γ</sub> + A<sub>γ</sub>type. A rapid technique for the isolation of <sub>γ</sub>CB-3 (<sub>γ</sub>l34–146) peptides in human fetal haemoglobin for G<sub>γ</sub>;A<sub>γ</sub>ratio determination is described. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Further Investigations of the γ-Chain in a Ghanaian Adult, Homozygous for Hereditary Persistence of Fetal Haemoglobin

Loading next page...
 
/lp/karger/further-investigations-of-the-chain-in-a-ghanaian-adult-homozygous-for-NgsyxI1x2G

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Karger
Copyright
© 1975 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000208198
Publisher site
See Article on Publisher Site

Abstract

The γ chain in a Ghanaian homozygous for hereditary persistence of fetal haemoglobin was considered to be of the G<sub>γ</sub>type on the basis of the amino acid analysis of <sub>γ</sub>Tp XIV (<sub>γ</sub>133–144) of the Hb F of this subject [1]. Recently, the sequence of residues <sub>γ</sub>134–137 of the <sub>γ</sub>-chain of this subject was determined and found to contain some alanine at position <sub>γ</sub>136. It is therefore of the G<sub>γ</sub> + A<sub>γ</sub>type. A rapid technique for the isolation of <sub>γ</sub>CB-3 (<sub>γ</sub>l34–146) peptides in human fetal haemoglobin for G<sub>γ</sub>;A<sub>γ</sub>ratio determination is described.

Journal

Acta HaematologicaKarger

Published: Jan 1, 1975

Keywords: γ-chains of Hb F; Dansyl-Edman technique; Fetal haemoglobin; Haemoglobinopathies; Hereditary persistence of Hb F

There are no references for this article.