Further Investigations of the γ-Chain in a Ghanaian Adult, Homozygous for Hereditary Persistence of Fetal Haemoglobin
Further Investigations of the γ-Chain in a Ghanaian Adult, Homozygous for Hereditary Persistence...
Kamuzora, H.; Ringelhann, B.; Konotey-Ahulu, F.I.D.; Lehmann, H.; Lorkin, P.A.
1975-01-01 00:00:00
The γ chain in a Ghanaian homozygous for hereditary persistence of fetal haemoglobin was considered to be of the G<sub>γ</sub>type on the basis of the amino acid analysis of <sub>γ</sub>Tp XIV (<sub>γ</sub>133–144) of the Hb F of this subject [1]. Recently, the sequence of residues <sub>γ</sub>134–137 of the <sub>γ</sub>-chain of this subject was determined and found to contain some alanine at position <sub>γ</sub>136. It is therefore of the G<sub>γ</sub> + A<sub>γ</sub>type. A rapid technique for the isolation of <sub>γ</sub>CB-3 (<sub>γ</sub>l34–146) peptides in human fetal haemoglobin for G<sub>γ</sub>;A<sub>γ</sub>ratio determination is described.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngActa HaematologicaKargerhttp://www.deepdyve.com/lp/karger/further-investigations-of-the-chain-in-a-ghanaian-adult-homozygous-for-NgsyxI1x2G
Further Investigations of the γ-Chain in a Ghanaian Adult, Homozygous for Hereditary Persistence of Fetal Haemoglobin
The γ chain in a Ghanaian homozygous for hereditary persistence of fetal haemoglobin was considered to be of the G<sub>γ</sub>type on the basis of the amino acid analysis of <sub>γ</sub>Tp XIV (<sub>γ</sub>133–144) of the Hb F of this subject [1]. Recently, the sequence of residues <sub>γ</sub>134–137 of the <sub>γ</sub>-chain of this subject was determined and found to contain some alanine at position <sub>γ</sub>136. It is therefore of the G<sub>γ</sub> + A<sub>γ</sub>type. A rapid technique for the isolation of <sub>γ</sub>CB-3 (<sub>γ</sub>l34–146) peptides in human fetal haemoglobin for G<sub>γ</sub>;A<sub>γ</sub>ratio determination is described.
Journal
Acta Haematologica
– Karger
Published: Jan 1, 1975
Keywords: γ-chains of Hb F; Dansyl-Edman technique; Fetal haemoglobin; Haemoglobinopathies; Hereditary persistence of Hb F
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