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Hypochromie der Erythrozyten bei heterozygotem Hämoglobin E (β26 Glu→Lys)

Hypochromie der Erythrozyten bei heterozygotem Hämoglobin E (β26 Glu→Lys) A family from south-western Germany with 9 heterozygous carriers of haemoglobin E (β26 Glu-Lys) is presented. The abnormal haemoglobin has been identified by different electrophoretic techniques and fingerprint analysis. In contrast to earlier observations, haemoglobin E is even in heterozygous carriers associated with erythrocytic hypochromia with MCH values from 23.6 to 26.2 pg. As an explanation for the hypochromia a decreased haemoglobin synthesis is supposed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Hypochromie der Erythrozyten bei heterozygotem Hämoglobin E (β26 Glu→Lys)

Keller, P.; Kohne, E.
Acta Haematologica , Volume 56 (5): 9 – Jan 1, 1976
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Publisher
Karger
Copyright
© 1976 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000207948
Publisher site
See Article on Publisher Site

Abstract

A family from south-western Germany with 9 heterozygous carriers of haemoglobin E (β26 Glu-Lys) is presented. The abnormal haemoglobin has been identified by different electrophoretic techniques and fingerprint analysis. In contrast to earlier observations, haemoglobin E is even in heterozygous carriers associated with erythrocytic hypochromia with MCH values from 23.6 to 26.2 pg. As an explanation for the hypochromia a decreased haemoglobin synthesis is supposed.

Journal

Acta Haematologica – Karger

Published: Jan 1, 1976

Keywords: Erythrocyte hypochromia; Haemoglobin E; Haemoglobinopathies

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