A New Case of Gamma-Heavy Chain Disease
Gallart, Teresa; Canals, Josep; Cañadell, Enric; Cortez, Lou; Moragas, August; Schwartz, Simon
1978-01-01 00:00:00
The first case of γ-heavy chain disease described in Spain is here reported. The patient, a 36-year-old woman, presented fever, enlarged regional lymph nodes, and hepatosplenomegaly, without bone marrow abnormalities but with lymphopenia. Serum electrophoresis did not disclose any M-component. The abnormal γ-chain protein had an α<sub>2</sub>-globulin mobility and was immunochemically related to the Fc fragment. It belonged to the IgG 4 subclass, its molecular weight was about 60,000. Proteinuria was minimal but the electrophoresis of concentrated urine showed a homogeneous peak of γ-globulin mobility constituted by the γ-chain fragment. Biopsy of an axillary lymph node disclosed features of immunoblastic sarcoma. The course was malignant, resulting in death in 8 months.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngActa HaematologicaKargerhttp://www.deepdyve.com/lp/karger/a-new-case-of-gamma-heavy-chain-disease-cFp5N0UHog
The first case of γ-heavy chain disease described in Spain is here reported. The patient, a 36-year-old woman, presented fever, enlarged regional lymph nodes, and hepatosplenomegaly, without bone marrow abnormalities but with lymphopenia. Serum electrophoresis did not disclose any M-component. The abnormal γ-chain protein had an α<sub>2</sub>-globulin mobility and was immunochemically related to the Fc fragment. It belonged to the IgG 4 subclass, its molecular weight was about 60,000. Proteinuria was minimal but the electrophoresis of concentrated urine showed a homogeneous peak of γ-globulin mobility constituted by the γ-chain fragment. Biopsy of an axillary lymph node disclosed features of immunoblastic sarcoma. The course was malignant, resulting in death in 8 months.
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.