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Relationship of Density Distribution and Pyruvate Kinase Electrophoretic Pattern of Erythrocytes in Sickle Cell Diseases and Other Disorders

Relationship of Density Distribution and Pyruvate Kinase Electrophoretic Pattern of Erythrocytes... The density distributions of red cells from sickle cell disorders and other hematological diseases were determined. In sickle cell anemia there was an increase in the proportion of cells in both the heaviest and lightest fractions. In hemoglobin SC disease, a small fraction was shifted to heavier cells. Sickle cell trait blood had a normal density pattern. In hereditary spherocytosis an increase in the number of heavy cells was observed. Thin-layer polyacrylamide gel electrophoresis of red cell pyruvate kinase demonstrated that the pyruvate kinase electrophoretic pattern was related to density distribution. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Relationship of Density Distribution and Pyruvate Kinase Electrophoretic Pattern of Erythrocytes in Sickle Cell Diseases and Other Disorders

Acta Haematologica , Volume 60 (4): 9 – Jan 1, 1978

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Publisher
Karger
Copyright
© 1978 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000207716
Publisher site
See Article on Publisher Site

Abstract

The density distributions of red cells from sickle cell disorders and other hematological diseases were determined. In sickle cell anemia there was an increase in the proportion of cells in both the heaviest and lightest fractions. In hemoglobin SC disease, a small fraction was shifted to heavier cells. Sickle cell trait blood had a normal density pattern. In hereditary spherocytosis an increase in the number of heavy cells was observed. Thin-layer polyacrylamide gel electrophoresis of red cell pyruvate kinase demonstrated that the pyruvate kinase electrophoretic pattern was related to density distribution.

Journal

Acta HaematologicaKarger

Published: Jan 1, 1978

Keywords: Red cell density distribution; Pyruvate kinase electrophoresis; Sickle cell diseases

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