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Differentiation Between Benign and Malignant Monoclonal Gammopathies by Discriminant Analysis on Serum and Bone Marrow Parameters

Differentiation Between Benign and Malignant Monoclonal Gammopathies by Discriminant Analysis on... Bone marrow samples of 28 individuals with clinically benign and of 41 patients with malignant monoclonal gammopathy were analyzed for the total number of lymphoplasmocellular elements containing cytoplasmic immunoglobulins and for the monoclonal fraction of these cells. Monoclonal immunoglobulin components were determined in sera. A discriminant analysis was performed on the data: the variables were transformed and in a stepwise procedure used for the construction of a discriminant function which by a dividing point allowed a good distinction between the two groups of patients. By use of this discriminant function, 91% of the patients in the sample were correctly classified. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Differentiation Between Benign and Malignant Monoclonal Gammopathies by Discriminant Analysis on Serum and Bone Marrow Parameters

Morell, A.; Maurer, W.; Skvaril, F.; Barandun, S.
Acta Haematologica , Volume 60 (3): 8 – Jan 1, 1978
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Publisher
Karger
Copyright
© 1978 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000207709
Publisher site
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Abstract

Bone marrow samples of 28 individuals with clinically benign and of 41 patients with malignant monoclonal gammopathy were analyzed for the total number of lymphoplasmocellular elements containing cytoplasmic immunoglobulins and for the monoclonal fraction of these cells. Monoclonal immunoglobulin components were determined in sera. A discriminant analysis was performed on the data: the variables were transformed and in a stepwise procedure used for the construction of a discriminant function which by a dividing point allowed a good distinction between the two groups of patients. By use of this discriminant function, 91% of the patients in the sample were correctly classified.

Journal

Acta Haematologica – Karger

Published: Jan 1, 1978

Keywords: Waldenström’s macroglobulinemia; Monoclonal gammopathies; Discriminant analysis; Multiple myeloma

There are no references for this article.