Hemoglobin Hasharon [α2 47 (CD5) Asp→ His β2]Linked to α-Thalassemia in Northern Italian Carriers
Hemoglobin Hasharon [α2 47 (CD5) Asp→ His β2]Linked to α-Thalassemia in Northern Italian Carriers
Mavilio, F.; Marinucci, M.; Massa, A.; Fontanarosa, P.P.; Tentori, L.; Cappellozza, G.
1980-01-01 00:00:00
This report is concerned with the evaluation of hematological parameters and of both relative (%) and absolute (mean pg/cell) quantities of the abnormal Hemoglobin (Hb) Hasharon in 53 heterozygous carriers and 7 double heterozygotes for Hb Hasharon and β-Thalassemia from 43 apparently unrelated families living in the province of Rovigo (northern Italy). Biosynthetic studies are also reported. The data strongly suggest the presence of an <sub>α</sub>-thalassemia-2 determinant closely linked to the α<sup>Hasharon</sup>-chain locus. Selective advantage of heterozygotes carrying such α-haplotype would explain the relatively high frequency of Hb Hasharon (0.23%) in northeastern Italy, a past-endemic malaria region. The interaction between Hb Hasharon and β-Thalassemia results in preferential decrease of the abnormal Hb level.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngActa HaematologicaKargerhttp://www.deepdyve.com/lp/karger/hemoglobin-hasharon-2-47-cd5-asp-his-2-linked-to-thalassemia-in-x77cxOhf0N
Hemoglobin Hasharon [α2 47 (CD5) Asp→ His β2]Linked to α-Thalassemia in Northern Italian Carriers
This report is concerned with the evaluation of hematological parameters and of both relative (%) and absolute (mean pg/cell) quantities of the abnormal Hemoglobin (Hb) Hasharon in 53 heterozygous carriers and 7 double heterozygotes for Hb Hasharon and β-Thalassemia from 43 apparently unrelated families living in the province of Rovigo (northern Italy). Biosynthetic studies are also reported. The data strongly suggest the presence of an <sub>α</sub>-thalassemia-2 determinant closely linked to the α<sup>Hasharon</sup>-chain locus. Selective advantage of heterozygotes carrying such α-haplotype would explain the relatively high frequency of Hb Hasharon (0.23%) in northeastern Italy, a past-endemic malaria region. The interaction between Hb Hasharon and β-Thalassemia results in preferential decrease of the abnormal Hb level.
To get new article updates from a journal on your personalized homepage, please log in first, or sign up for a DeepDyve account if you don’t already have one.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.