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The Iron Uptake by Reticulocytes in Normal Subjects, in Subjects with Thalassaemia Minor and in Patients with Thalassaemia Major

The Iron Uptake by Reticulocytes in Normal Subjects, in Subjects with Thalassaemia Minor and in... Acta haemal. 29: 80-88 (1963). From the D epartm ent of Clinical T herapeutics, University of Athens an d the R adio­ isotope L aboratory, A lexandra Hospital, Athens T h e I r o n U p ta k e by R e tic u lo c y te s in N o rm a l S u b jec ts, in S u b je c ts w ith T h a la s s a e m ia M in o r a n d in P a tie n ts w ith T h a la s s a e m ia M ajo r* In vitro Studies By B. M alamos, E. G yftaki and Ch. P roukakis It is known that normoblasts continue to incorporate iron and synthesize haemoglobin in vitro (7). The reticulocytes also retain the same ability, but to a lesser degree (8). There is no iron up­ take by mature red cells because the haemoglobin synthesis has been completed at the reticulocyte stage. The fact that mature red cells do not incorporate iron facilitates the study of iron metabolism and haemoglobin synthesis in vitro by reticulocytes. In the present paper http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

The Iron Uptake by Reticulocytes in Normal Subjects, in Subjects with Thalassaemia Minor and in Patients with Thalassaemia Major

Acta Haematologica , Volume 29 (2): 9 – Jan 1, 2009

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Publisher
Karger
Copyright
© 1963 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000207327
Publisher site
See Article on Publisher Site

Abstract

Acta haemal. 29: 80-88 (1963). From the D epartm ent of Clinical T herapeutics, University of Athens an d the R adio­ isotope L aboratory, A lexandra Hospital, Athens T h e I r o n U p ta k e by R e tic u lo c y te s in N o rm a l S u b jec ts, in S u b je c ts w ith T h a la s s a e m ia M in o r a n d in P a tie n ts w ith T h a la s s a e m ia M ajo r* In vitro Studies By B. M alamos, E. G yftaki and Ch. P roukakis It is known that normoblasts continue to incorporate iron and synthesize haemoglobin in vitro (7). The reticulocytes also retain the same ability, but to a lesser degree (8). There is no iron up­ take by mature red cells because the haemoglobin synthesis has been completed at the reticulocyte stage. The fact that mature red cells do not incorporate iron facilitates the study of iron metabolism and haemoglobin synthesis in vitro by reticulocytes. In the present paper

Journal

Acta HaematologicaKarger

Published: Jan 1, 2009

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