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Ultrastructural Studies of an Unusual Variant of Congenital Dyserythropoietic Anaemia Type II

Ultrastructural Studies of an Unusual Variant of Congenital Dyserythropoietic Anaemia Type II Electron microscopy of a new variant of congenital dyserythropoietic anaemia type II has yielded several unexpected results. The remarkable features include the relatively high percentage of erythrocytes with peripheral cisternae, the involvement of all bone marrow precursor cells, and the presence of ultrastructural defects in the granulocytes and platelets and on the cell surface of the erythrocytes. Experiments with vinblastine showed that this drug was capable of producing (in vitro) strikingly similar ultrastructural defects in healthy erythrocytes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Ultrastructural Studies of an Unusual Variant of Congenital Dyserythropoietic Anaemia Type II

Dewar, Catharine L.; Lowenthal, Ray M.
Acta Haematologica , Volume 64 (1): 5 – Jan 1, 1980
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Publisher
Karger
Copyright
© 1980 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000207210
Publisher site
See Article on Publisher Site

Abstract

Electron microscopy of a new variant of congenital dyserythropoietic anaemia type II has yielded several unexpected results. The remarkable features include the relatively high percentage of erythrocytes with peripheral cisternae, the involvement of all bone marrow precursor cells, and the presence of ultrastructural defects in the granulocytes and platelets and on the cell surface of the erythrocytes. Experiments with vinblastine showed that this drug was capable of producing (in vitro) strikingly similar ultrastructural defects in healthy erythrocytes.

Journal

Acta Haematologica – Karger

Published: Jan 1, 1980

Keywords: CDA II; Electron microscopy; Erythrocytes; Granulocytes; Kell blood group; Platelets

There are no references for this article.