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The Role of HF Cofactor in the Hageman Factor-Dependent Fibrinolytic Mechanism

The Role of HF Cofactor in the Hageman Factor-Dependent Fibrinolytic Mechanism In 1969, Ogston et al. reported that the normal activation of fibrinolysis by surface contact requires, in addition to Hageman factor and plasminogen, a HF cofactor which is present in the euglobulin fraction and other factor(s) present in the supernatant. It has also been suggested that the glass-treated plasma is deficient in HF cofactor. In our laboratory the glass-treated plasma was found not to be deficient in HF or in a strepto-kinase-activated proactivator or m plasminogen. The glass-treated plasma was found deficient in prekallikrein in kininogen and in clotting factors XI, IX, VIII and V. The results presented indicate that HF cofactor activity is not different from that of kallikrein and that HF cofactor does not act as a plasminogen proactivator. Furthermore, the results indicate that the ‘other factors’ present in the supernatant are not involved in contact-activated fibrinolysis. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

The Role of HF Cofactor in the Hageman Factor-Dependent Fibrinolytic Mechanism

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Publisher
Karger
Copyright
© 1981 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000207131
Publisher site
See Article on Publisher Site

Abstract

In 1969, Ogston et al. reported that the normal activation of fibrinolysis by surface contact requires, in addition to Hageman factor and plasminogen, a HF cofactor which is present in the euglobulin fraction and other factor(s) present in the supernatant. It has also been suggested that the glass-treated plasma is deficient in HF cofactor. In our laboratory the glass-treated plasma was found not to be deficient in HF or in a strepto-kinase-activated proactivator or m plasminogen. The glass-treated plasma was found deficient in prekallikrein in kininogen and in clotting factors XI, IX, VIII and V. The results presented indicate that HF cofactor activity is not different from that of kallikrein and that HF cofactor does not act as a plasminogen proactivator. Furthermore, the results indicate that the ‘other factors’ present in the supernatant are not involved in contact-activated fibrinolysis.

Journal

Acta HaematologicaKarger

Published: Jan 1, 1981

Keywords: Kallikrein; Fibrinolysis; Hageman factor; Hageman factor-cofactor

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