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Increased Alpha-2-Macroglobulin in Opiate Addicts: Further Evidence of an Alteration in the Coagulation System due to Opiate Addiction

Increased Alpha-2-Macroglobulin in Opiate Addicts: Further Evidence of an Alteration in the... Correspondence © 1985 S.Karger AG, Basel 0001 -5792/85/0732-0117 S 2.75/0 Acta haemat. 73: 117(1985) Increased Alpha-2-MacrogIobulin in Opiate Addicts: Further Evidence o f an Alteration in the Coagulation System due to Opiate Addiction 4 Passariello, N.; Giugliano, D.; Quatraro, A.; Consoli, G.; Sgam­ Increased plasma levels of a 2-macroglobulin, a bato, S.; Torella, R.; D’Onofrio, F.: Glucose tolerance and hor­ natural linhibitor of blood coagulation, have been re­ monal responses in heroin addicts. A possible role for endoge­ ported in diabetes [1]. We have previously reported nous opiates in the pathogenesis of non-insulin dependent dia­ that opiate addicts behave similarly to diabetics [2-4], betes. Metabolism 32: 1163-1165(1983). Therefore, we measured blood glucose, Hb Ai and cq- 5 Passariello, N.; Giugliano, D.; Ceriello, A.; Misso, L.; Qua­ traro, A.: Increased platelet aggregation in opiate addicts. macroglobulin in 20 male addicts (mean ag e± S D Blood 60: 276(1982). 23 ± 3.4 years) and in 20 healthy male controls (age 6 Ceriello, A.; Dello Russo, P.; Niola, O.; Schimizzi, S.; Capez- 23 ± 2.5 years). Hb Ai and a 2-macroglobulin were zuto, C.: Fibrinogen levels in opiate addicts. Thromb. Haemos­ found to be significantly increased in addicts (Hb A| tasis 50: 759(1983). 7.2 ±0.14%; a 2-macroglobulin 243.26 ± 62.2 mg/dl) 7 Ceriello, A.; Dello Russo, P.; Curcio, F.; Tirelli, A.; Giugliano, D.: Depressed antithrombin III biological activity in opiate ad­ versus controls (Hb Ai 6.3 ± 0.17%, p < 0.001; a 2-mac- dicts. J.clin. Path. 37: 1040-1042(1984). roglobulin 156.91 ± 37.32 m g/dl, p <0.001). No corre­ 8 Sagel, J.; Colwell, J.A.; Crook, L.; Laimins, M.: Increased plate­ lation was found between Hb Ai and a 2-macroglobu- let aggregation in early diabetes mellitus. Ann. intern. Med. lin levels. Our data demonstrate increased CQ-macro- 82: 733-735(1975). globulin levels in opiate addicts and confirm the 9 Coller, B.S.; Frank, D.N.: Milton, R.C.: Plasma co-factors of platelet function. Correlation with retinopathy 'and haemo­ occurrence of an impairment of the blood clotting globin A|a_c. Ann. intern. Med. 88: 311-315 (1978). mechanism in the same addicts [5-7], in analogy to 10 Ceriello, A.; Dello Russo, P.; Zuccotti, C.; Florio, A.; Nazzaro, that found in diabetics [8-10]. S.; Pietrantuono, C.; Rosato, G.B.: Decreased antithrombin III activity in diabetes may be due to non-enzymatic glycosylation. A preliminary report. Thromb. Haemostasis 50: 633-634 (1983). References 1 Fuller, J.H.; Keen, H.; Jarrett, R.J.: Hemostatic variables asso­ Accepted: January 1,1985 ciated with diabetes and its complications. Br. med. J. ii: Antonio Ceriello, Patrizia Dello Russo, 964-966(1979). 2 Ceriello, A.; Giugliano, D.; Dello Russo, P.; Sgambato, S.; Francesco Curcio, Nicola Passariello, Dario Giugliano, D’Onofrio, F.: Increased glycosylated haemoglobin A, in opiate Istituto di Patologia Medica, addicts: evidence for hyperglycaemic effect of morphine. Dia- I Facoltà di Medicina, betologia 22: 379(1982). 3 Ceriello, A.; Dello Russo, P.; Curcio, F.; Rossano, P.: Increased Université di Napoli, glycosylated protein in opiate addicts. Diabetes Care 7:104-105 Piazza Miraglia, (1984). 1-80138 Napoli (Italy) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Increased Alpha-2-Macroglobulin in Opiate Addicts: Further Evidence of an Alteration in the Coagulation System due to Opiate Addiction

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Publisher
Karger
Copyright
© 1985 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000206295
Publisher site
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Abstract

Correspondence © 1985 S.Karger AG, Basel 0001 -5792/85/0732-0117 S 2.75/0 Acta haemat. 73: 117(1985) Increased Alpha-2-MacrogIobulin in Opiate Addicts: Further Evidence o f an Alteration in the Coagulation System due to Opiate Addiction 4 Passariello, N.; Giugliano, D.; Quatraro, A.; Consoli, G.; Sgam­ Increased plasma levels of a 2-macroglobulin, a bato, S.; Torella, R.; D’Onofrio, F.: Glucose tolerance and hor­ natural linhibitor of blood coagulation, have been re­ monal responses in heroin addicts. A possible role for endoge­ ported in diabetes [1]. We have previously reported nous opiates in the pathogenesis of non-insulin dependent dia­ that opiate addicts behave similarly to diabetics [2-4], betes. Metabolism 32: 1163-1165(1983). Therefore, we measured blood glucose, Hb Ai and cq- 5 Passariello, N.; Giugliano, D.; Ceriello, A.; Misso, L.; Qua­ traro, A.: Increased platelet aggregation in opiate addicts. macroglobulin in 20 male addicts (mean ag e± S D Blood 60: 276(1982). 23 ± 3.4 years) and in 20 healthy male controls (age 6 Ceriello, A.; Dello Russo, P.; Niola, O.; Schimizzi, S.; Capez- 23 ± 2.5 years). Hb Ai and a 2-macroglobulin were zuto, C.: Fibrinogen levels in opiate addicts. Thromb. Haemos­ found to be significantly increased in addicts (Hb A| tasis 50: 759(1983). 7.2 ±0.14%; a 2-macroglobulin 243.26 ± 62.2 mg/dl) 7 Ceriello, A.; Dello Russo, P.; Curcio, F.; Tirelli, A.; Giugliano, D.: Depressed antithrombin III biological activity in opiate ad­ versus controls (Hb Ai 6.3 ± 0.17%, p < 0.001; a 2-mac- dicts. J.clin. Path. 37: 1040-1042(1984). roglobulin 156.91 ± 37.32 m g/dl, p <0.001). No corre­ 8 Sagel, J.; Colwell, J.A.; Crook, L.; Laimins, M.: Increased plate­ lation was found between Hb Ai and a 2-macroglobu- let aggregation in early diabetes mellitus. Ann. intern. Med. lin levels. Our data demonstrate increased CQ-macro- 82: 733-735(1975). globulin levels in opiate addicts and confirm the 9 Coller, B.S.; Frank, D.N.: Milton, R.C.: Plasma co-factors of platelet function. Correlation with retinopathy 'and haemo­ occurrence of an impairment of the blood clotting globin A|a_c. Ann. intern. Med. 88: 311-315 (1978). mechanism in the same addicts [5-7], in analogy to 10 Ceriello, A.; Dello Russo, P.; Zuccotti, C.; Florio, A.; Nazzaro, that found in diabetics [8-10]. S.; Pietrantuono, C.; Rosato, G.B.: Decreased antithrombin III activity in diabetes may be due to non-enzymatic glycosylation. A preliminary report. Thromb. Haemostasis 50: 633-634 (1983). References 1 Fuller, J.H.; Keen, H.; Jarrett, R.J.: Hemostatic variables asso­ Accepted: January 1,1985 ciated with diabetes and its complications. Br. med. J. ii: Antonio Ceriello, Patrizia Dello Russo, 964-966(1979). 2 Ceriello, A.; Giugliano, D.; Dello Russo, P.; Sgambato, S.; Francesco Curcio, Nicola Passariello, Dario Giugliano, D’Onofrio, F.: Increased glycosylated haemoglobin A, in opiate Istituto di Patologia Medica, addicts: evidence for hyperglycaemic effect of morphine. Dia- I Facoltà di Medicina, betologia 22: 379(1982). 3 Ceriello, A.; Dello Russo, P.; Curcio, F.; Rossano, P.: Increased Université di Napoli, glycosylated protein in opiate addicts. Diabetes Care 7:104-105 Piazza Miraglia, (1984). 1-80138 Napoli (Italy)

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Acta Haematologica – Karger

Published: Jan 1, 1985

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