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Bone Marrow Fibroblasts in Acute Lymphoblastic Leukemia

Bone Marrow Fibroblasts in Acute Lymphoblastic Leukemia Fibroblast-like cells were grown from the bone marrow of acute lymphoblastic leukemia (ALL) patients before, during and off therapy. A diminished growth capacity was observed in cells from patients before and during therapy. In the three groups studied, differences were also observed in the effect of hydrocortisone on DNA synthesis and in the content of glucocorticoid binding sites. These results suggest that microenvironmental changes occur in ALL, which may revert to normality during or after therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Bone Marrow Fibroblasts in Acute Lymphoblastic Leukemia

Acta Haematologica , Volume 73 (2): 5 – Jan 1, 1985

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Publisher
Karger
Copyright
© 1985 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000206284
Publisher site
See Article on Publisher Site

Abstract

Fibroblast-like cells were grown from the bone marrow of acute lymphoblastic leukemia (ALL) patients before, during and off therapy. A diminished growth capacity was observed in cells from patients before and during therapy. In the three groups studied, differences were also observed in the effect of hydrocortisone on DNA synthesis and in the content of glucocorticoid binding sites. These results suggest that microenvironmental changes occur in ALL, which may revert to normality during or after therapy.

Journal

Acta HaematologicaKarger

Published: Jan 1, 1985

Keywords: Stroma; Bone marrow; Fibroblasts; Glucocorticoids; Receptors

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