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Effects of Lithium on the Platelet Count in Neoplastic Patients Treated with Polychemotherapy

Effects of Lithium on the Platelet Count in Neoplastic Patients Treated with Polychemotherapy © 1986 S. K arger A G , Basel 0 0 0 1 -5 7 9 2 /8 6 /0 7 5 4 -0 2 4 2 $ 2 .7 5 /0 A ctahaem at. 75 : 242-243(1986) Effects o f Lithium on the Platelet Count in Neoplastic Patients Treated with Polychemotherapy The ability of lithium to induce neutrophil leuko­ was normalised by lithium did not exhibit a satisfac­ cytosis [1] has made it possible to use this drug to at­ tory neutrophil response (neutrophils > 2 x 109/1). On tenuate and to control myelodepression induced by the other hand, 2 of the 3 patients whose platelet chemotherapy in neoplastic patients [2-4], count did not increase revealed a good neutrophil re­ Furthermore, the effectiveness of lithium has been sponse. clinically demonstrated in rare forms of chronic neu­ Monocytes showed a significant increase in 6 out tropenia [5] and neutropathy [6], and experiments of the 8 patients (0.253 ± 0.102 x 109/1 vs. 0.165 have indicated that this drug is capable of modulating ± 0.082 x 109/ l ; p < 0.025). the microtubular system of human neutrophils [7, 8]. In a control group, made up of 9 patients with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Effects of Lithium on the Platelet Count in Neoplastic Patients Treated with Polychemotherapy

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Publisher
Karger
Copyright
© 1986 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000206135
Publisher site
See Article on Publisher Site

Abstract

© 1986 S. K arger A G , Basel 0 0 0 1 -5 7 9 2 /8 6 /0 7 5 4 -0 2 4 2 $ 2 .7 5 /0 A ctahaem at. 75 : 242-243(1986) Effects o f Lithium on the Platelet Count in Neoplastic Patients Treated with Polychemotherapy The ability of lithium to induce neutrophil leuko­ was normalised by lithium did not exhibit a satisfac­ cytosis [1] has made it possible to use this drug to at­ tory neutrophil response (neutrophils > 2 x 109/1). On tenuate and to control myelodepression induced by the other hand, 2 of the 3 patients whose platelet chemotherapy in neoplastic patients [2-4], count did not increase revealed a good neutrophil re­ Furthermore, the effectiveness of lithium has been sponse. clinically demonstrated in rare forms of chronic neu­ Monocytes showed a significant increase in 6 out tropenia [5] and neutropathy [6], and experiments of the 8 patients (0.253 ± 0.102 x 109/1 vs. 0.165 have indicated that this drug is capable of modulating ± 0.082 x 109/ l ; p < 0.025). the microtubular system of human neutrophils [7, 8]. In a control group, made up of 9 patients with

Journal

Acta Haematologica – Karger

Published: Jan 1, 1986

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