Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Leukaemic Meningitis in Chronic Lymphocytic Leukaemia

Leukaemic Meningitis in Chronic Lymphocytic Leukaemia A patient with chronic lymphocytic leukaemia (CLL) who developed leukaemic meningitis, after chemotherapy had successfully reduced the tumour load, is described. This progressed rapidly as basal meningitis and caused almost a complete obstruction of the lateral ventricles, palsy of several cranial nerves and deep coma. The diagnosis of leukaemic meningitis was nevertheless considerably delayed, as other forms of lymphocytic meningitis were excluded. Intrathecal methotrexate, followed by cranial irradiation led to complete resolution of neurological signs and symptoms and a rapid clearance of CSF of leukaemic cells. It is likely that immunological characterization of the CSF lymphocytes would help early diagnosis of such patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Leukaemic Meningitis in Chronic Lymphocytic Leukaemia

Singh, A.K.S.; Thompson, R.P.H.
Acta Haematologica , Volume 75 (2): 3 – Jan 1, 1986
Download PDF
3 pages

Loading next page...
 
/lp/karger/leukaemic-meningitis-in-chronic-lymphocytic-leukaemia-ARSdyYVrhm

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Karger
Copyright
© 1986 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000206098
Publisher site
See Article on Publisher Site

Abstract

A patient with chronic lymphocytic leukaemia (CLL) who developed leukaemic meningitis, after chemotherapy had successfully reduced the tumour load, is described. This progressed rapidly as basal meningitis and caused almost a complete obstruction of the lateral ventricles, palsy of several cranial nerves and deep coma. The diagnosis of leukaemic meningitis was nevertheless considerably delayed, as other forms of lymphocytic meningitis were excluded. Intrathecal methotrexate, followed by cranial irradiation led to complete resolution of neurological signs and symptoms and a rapid clearance of CSF of leukaemic cells. It is likely that immunological characterization of the CSF lymphocytes would help early diagnosis of such patients.

Journal

Acta Haematologica – Karger

Published: Jan 1, 1986

Keywords: Chronic lymphocytic leukaemia; Leukaemic meningitis

There are no references for this article.