Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Variations in Morphological and Immunological Blast Cell Phenotype in a Case of Acute Leukaemia with t(4;11) Translocation

Variations in Morphological and Immunological Blast Cell Phenotype in a Case of Acute Leukaemia... A case of acute leukaemia with t(4;l 1) chromosomal abnormality in a 28-year-old woman is reported. At diagnosis, two blast cell populations were seen: 60% of the cells were small cells with lymphoid morphology, 40% were large cells with monocytic morphology. Cytochemical examination was consistent with acute myeloid leukaemia (peroxidase-positive in 10% of the cells), but surface markers were those of common acute lymphoblastic leukaemia (CALLA, B4, TdT-positive, but My7-, My9- and OKM1-negative). Five days after diagnosis, although the only treatment had been platelet transfusions, there was a change in morphological and immunological phenotype: 40% of the cells were lymphoid and 60% monocytic. Lymphoid markers were expressed in only 20–40% of cells, and myeloid markers appeared on up to 60% of cells. We conclude that t(4;l 1) leukaemia could originate in an undifferentiated progenitor cell, which can undergo further differentiation into lymphoblasts or monoblasts, and that we were able to observe this in vivo differentiation in our patient. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Variations in Morphological and Immunological Blast Cell Phenotype in a Case of Acute Leukaemia with t(4;11) Translocation

Download PDF
4 pages

Loading next page...
 
/lp/karger/variations-in-morphological-and-immunological-blast-cell-phenotype-in-yrmG0D0mpM

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Karger
Copyright
© 1986 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000206046
Publisher site
See Article on Publisher Site

Abstract

A case of acute leukaemia with t(4;l 1) chromosomal abnormality in a 28-year-old woman is reported. At diagnosis, two blast cell populations were seen: 60% of the cells were small cells with lymphoid morphology, 40% were large cells with monocytic morphology. Cytochemical examination was consistent with acute myeloid leukaemia (peroxidase-positive in 10% of the cells), but surface markers were those of common acute lymphoblastic leukaemia (CALLA, B4, TdT-positive, but My7-, My9- and OKM1-negative). Five days after diagnosis, although the only treatment had been platelet transfusions, there was a change in morphological and immunological phenotype: 40% of the cells were lymphoid and 60% monocytic. Lymphoid markers were expressed in only 20–40% of cells, and myeloid markers appeared on up to 60% of cells. We conclude that t(4;l 1) leukaemia could originate in an undifferentiated progenitor cell, which can undergo further differentiation into lymphoblasts or monoblasts, and that we were able to observe this in vivo differentiation in our patient.

Journal

Acta Haematologica – Karger

Published: Jan 1, 1986

Keywords: Chromosome t(4;l 1) translocation; Lymphoblastic leukaemia, acute; Mixed leukaemia; Monoblastic leukaemia, acute; Myeloid-associated antigens

There are no references for this article.