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Corticosteroid and Factor VIII

Corticosteroid and Factor VIII © 1989S. Karger AG, Basel 0001 -5792/89/0814-0222 $ 2.75/0 Acta Haemat 1989;81:222 §inasi Ozsoylu Hematology Unit, D epartm ent of Pediatrics, Hacettepe University Faculty o f Medicine and Hacettepe C hildren’s Hospital, Ankara, Turkey Dr. Casonato et al. [1] in their recent paper entitled 2 Dal Bo Zanon, R.: Fornasiero, L.; Boscaro, M.; C apellato, G.; Fabris F.; G rolom i, A.: Increased factor VIII associated activity ‘Factor V U I/von Willebrand factor abnormalities in Cushing’s syndrome. A probable hypercoagulable state. during L-asparaginase treatment in patients with Thromb. Haemostasis 47: 116-117 (1982). acute lymphoblastic leukemia’ have definitely shown 3 Ozsoylu, §.; Strauss, H.S.; Diam ond, L.K.: Effects o f corticoste­ that factor VIII:C activity is markedly elevated in roids on coagulation o f the blood. Nature, Lond. 195: their patients. Some abnormality of von Willebrand 1214-1215(1962). 4 Ozsoylu, §.; Tugcu, K.; Coteli, I.; Kavcioglu, H.; Urkmez, M.; factor (vWF) was also detected in their patients by Giirsel, T.: Effect o f intravenous adrenalin infusion and corti­ cross-immunolectrophoresis. ‘Greater increase of costeroid in patients with von W illebrand’s disease. Acta hae­ VIII:C’ due to corticosteroids was brought to the at­ mat. 64: 289-293(1980). tention by the authors by referring to the study of Dal 5 Ozsoylu, Comments to the paper by Jorgensen et al. Acta Bo Zanon et al. [2], This was actually first shown by us haemat. 70: 70(1983). [3] 20 year earlier not only in a patient with Cushing’s syndrome, but it was also indicated in patients with hemophilia A and von Willebrand’s disease who were given corticosteroids [4, 5]. Since I have not found factor VIII:C and vWF values following discontinuation of /^asparaginase treatment, it is hard for me to accept the relationship between these changes and their use, except vWF abnormality. References §inasi Ozsoylu, MD 1 Casonato, A.; Lazzaro, A.R.; Rosolen, A.; Girolam i, A.: Factor Department of Pediatrics, Hematology Unit V U I/von Willebrand factor abnormalities during /^asparagi­ Hacettepe University Faculty o f Medicine nase treatm ent in patients with acute lymphoblastic leukemia. Hacettepe Children’s Hospital Acta haemat. 80: 190-193 (1988). Ankara 06100 (Turkey) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Corticosteroid and Factor VIII

Özsoylu, Şinasi
Acta Haematologica , Volume 81 (4): 1 – Jan 1, 1989
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References (5)

Publisher
Karger
Copyright
© 1989 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000205568
Publisher site
See Article on Publisher Site

Abstract

© 1989S. Karger AG, Basel 0001 -5792/89/0814-0222 $ 2.75/0 Acta Haemat 1989;81:222 §inasi Ozsoylu Hematology Unit, D epartm ent of Pediatrics, Hacettepe University Faculty o f Medicine and Hacettepe C hildren’s Hospital, Ankara, Turkey Dr. Casonato et al. [1] in their recent paper entitled 2 Dal Bo Zanon, R.: Fornasiero, L.; Boscaro, M.; C apellato, G.; Fabris F.; G rolom i, A.: Increased factor VIII associated activity ‘Factor V U I/von Willebrand factor abnormalities in Cushing’s syndrome. A probable hypercoagulable state. during L-asparaginase treatment in patients with Thromb. Haemostasis 47: 116-117 (1982). acute lymphoblastic leukemia’ have definitely shown 3 Ozsoylu, §.; Strauss, H.S.; Diam ond, L.K.: Effects o f corticoste­ that factor VIII:C activity is markedly elevated in roids on coagulation o f the blood. Nature, Lond. 195: their patients. Some abnormality of von Willebrand 1214-1215(1962). 4 Ozsoylu, §.; Tugcu, K.; Coteli, I.; Kavcioglu, H.; Urkmez, M.; factor (vWF) was also detected in their patients by Giirsel, T.: Effect o f intravenous adrenalin infusion and corti­ cross-immunolectrophoresis. ‘Greater increase of costeroid in patients with von W illebrand’s disease. Acta hae­ VIII:C’ due to corticosteroids was brought to the at­ mat. 64: 289-293(1980). tention by the authors by referring to the study of Dal 5 Ozsoylu, Comments to the paper by Jorgensen et al. Acta Bo Zanon et al. [2], This was actually first shown by us haemat. 70: 70(1983). [3] 20 year earlier not only in a patient with Cushing’s syndrome, but it was also indicated in patients with hemophilia A and von Willebrand’s disease who were given corticosteroids [4, 5]. Since I have not found factor VIII:C and vWF values following discontinuation of /^asparaginase treatment, it is hard for me to accept the relationship between these changes and their use, except vWF abnormality. References §inasi Ozsoylu, MD 1 Casonato, A.; Lazzaro, A.R.; Rosolen, A.; Girolam i, A.: Factor Department of Pediatrics, Hematology Unit V U I/von Willebrand factor abnormalities during /^asparagi­ Hacettepe University Faculty o f Medicine nase treatm ent in patients with acute lymphoblastic leukemia. Hacettepe Children’s Hospital Acta haemat. 80: 190-193 (1988). Ankara 06100 (Turkey)

Journal

Acta Haematologica – Karger

Published: Jan 1, 1989

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