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In vivo Dose-Response Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on Increase in Granulocytes after Peripheral Blood Stem Cell Autotransplantation

In vivo Dose-Response Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on... The in vivo dose-response potential of recombinant human granulocyte colony-stimulating factor (rG-CSF) in facilitating reconstitution of granulopoiesis was evaluated in an 11-year-old girl who received autotransplantation of peripheral blood stem cells (PBSC) after marrow-ablative therapy for relapsing acute lymphoblastic leukemia. The recovery of hematopoiesis was slow when a small number of progenitors were collected and reinfused into the patient, but administration of rG-CSF led to significant dose-dependent increase in peripheral blood granulocytes. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

In vivo Dose-Response Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on Increase in Granulocytes after Peripheral Blood Stem Cell Autotransplantation

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Publisher
Karger
Copyright
© 1989 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000205563
Publisher site
See Article on Publisher Site

Abstract

The in vivo dose-response potential of recombinant human granulocyte colony-stimulating factor (rG-CSF) in facilitating reconstitution of granulopoiesis was evaluated in an 11-year-old girl who received autotransplantation of peripheral blood stem cells (PBSC) after marrow-ablative therapy for relapsing acute lymphoblastic leukemia. The recovery of hematopoiesis was slow when a small number of progenitors were collected and reinfused into the patient, but administration of rG-CSF led to significant dose-dependent increase in peripheral blood granulocytes.

Journal

Acta HaematologicaKarger

Published: Jan 1, 1989

Keywords: Autotransplantation; Circulating hematopoietic stem cell; Granulocyte colony-stimulating factor

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