In vivo Dose-Response Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on Increase in Granulocytes after Peripheral Blood Stem Cell Autotransplantation
In vivo Dose-Response Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on...
Takaue, Yoichi; Koyama, Tetsuya; Watanabe, Tsutomu; Kawano, Yoshifumi; Ninomiya, Tsuneo; Kuroda, Yasuhiro; Hiraoka, Akira; Masaoka, Tohru
1989-01-01 00:00:00
The in vivo dose-response potential of recombinant human granulocyte colony-stimulating factor (rG-CSF) in facilitating reconstitution of granulopoiesis was evaluated in an 11-year-old girl who received autotransplantation of peripheral blood stem cells (PBSC) after marrow-ablative therapy for relapsing acute lymphoblastic leukemia. The recovery of hematopoiesis was slow when a small number of progenitors were collected and reinfused into the patient, but administration of rG-CSF led to significant dose-dependent increase in peripheral blood granulocytes.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngActa HaematologicaKargerhttp://www.deepdyve.com/lp/karger/in-vivo-dose-response-effect-of-recombinant-human-granulocyte-colony-0tARAVK5Mp
In vivo Dose-Response Effect of Recombinant Human Granulocyte Colony-Stimulating Factor on Increase in Granulocytes after Peripheral Blood Stem Cell Autotransplantation
The in vivo dose-response potential of recombinant human granulocyte colony-stimulating factor (rG-CSF) in facilitating reconstitution of granulopoiesis was evaluated in an 11-year-old girl who received autotransplantation of peripheral blood stem cells (PBSC) after marrow-ablative therapy for relapsing acute lymphoblastic leukemia. The recovery of hematopoiesis was slow when a small number of progenitors were collected and reinfused into the patient, but administration of rG-CSF led to significant dose-dependent increase in peripheral blood granulocytes.
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