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Isodicentric X Chromosome in Myeloproliferative Disorders

Isodicentric X Chromosome in Myeloproliferative Disorders Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Haematologica Karger

Isodicentric X Chromosome in Myeloproliferative Disorders

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Publisher
Karger
Copyright
© 1989 S. Karger AG, Basel
ISSN
0001-5792
eISSN
1421-9662
DOI
10.1159/000205549
Publisher site
See Article on Publisher Site

Abstract

Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration.

Journal

Acta HaematologicaKarger

Published: Jan 1, 1989

Keywords: Chronic myelogenous leukemia; Isochromosome i(X)(q13); Myelofibrosis

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