Isodicentric X Chromosome in Myeloproliferative Disorders
Isodicentric X Chromosome in Myeloproliferative Disorders
Temperani, Paola; Zucchini, Patrizia; Emilia, Giovanni; Sacchi, Stefano; Selleri, Licia; Torelli, Umberto
1989-01-01 00:00:00
Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngActa HaematologicaKargerhttp://www.deepdyve.com/lp/karger/isodicentric-x-chromosome-in-myeloproliferative-disorders-03xN2RbyTZ
Isodicentric X Chromosome in Myeloproliferative Disorders
Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration.
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