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/lp/karger/proliferation-of-b-cells-from-chronic-lymphocytic-leukemia-is-naH0EtSFlV
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- Publisher
- Karger
- Copyright
- © 1989 S. Karger AG, Basel
- ISSN
- 0001-5792
- eISSN
- 1421-9662
- DOI
- 10.1159/000205533
- Publisher site
- See Article on Publisher Site
Abstract
B cell activation was studied in B cells from B cell chronic lymphocytic leukemia (B-CLL) patients. After in vitro stimulation, these B cells showed extensive proliferation in the presence of high-molecular-weight B cell growth factor (BCGF). In contrast, this effect was not observed upon addition of recombinant interleukin-2 (IL-2). In agreement, upon stimulation, B cells expressed Bac-1 antigen but failed to acquire the IL-2 receptor. These results demonstrate that the utilization of the BCGF pathway can be segregated from that of IL-2 in B cells from B-CLL patients.
Journal
Acta Haematologica – Karger
Published: Jan 1, 1989
Keywords: B cell chronic lymphocytic leukemia; B cell growth factor; Interleukin-2; Proliferation